| Switchable Catalytic Acrylamide Hydrogels Crosslinked by Hemin/G-Quadruplexes. | |
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MedLine Citation:
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PMID: 23421921 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Copolymer chains consisting of acrylamide units and guanine (G)-containing oligonucleotide-tethered acrylamide units undergo in the presence of K(+) ions, crosslinking by G-quadruplexes to yield a hydrogel. The hydrogel is dissociated upon addition of 18-crown-6 ether that traps the K(+) ions. Reversible formation and dissociation of the hydrogel is demonstrated by the cyclic addition of K(+) ions and 18-crown-6 ether, respectively. Formation of the hydrogel in the presence of hemin results in a hemin/G-quadruplex-crosslinked catalytic hydrogel mimicking the function of horseradish peroxidase, reflected by the catalyzed oxidation of 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid), ABTS(2-), by H(2)O(2) to ABTS(.-) and by the catalyzed generation of chemiluminescence in the presence of luminol/ H(2)O(2). Cyclic "ON" and "OFF" activation of the catalytic functions of the hydrogel are demonstrated upon the formation of the hydrogel in the presence of K(+) ions and its dissociation by 18-crown-6 ether, respectively. The hydrogel is characterized by rheology measurements, circular dichroism and by probing its chemical and photophysical properties. |
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Authors:
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Chun-Hua Lu; Xiu-Juan Qi; Ron Orbach; Huang-Hao Yang; Iris Mironi-Harpaz; Dror Seliktar; Itamar Willner |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-20 |
Journal Detail:
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Title: Nano letters Volume: - ISSN: 1530-6992 ISO Abbreviation: Nano Lett. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101088070 Medline TA: Nano Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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