Document Detail


The Switch from Fetal to Adult Hemoglobin.
MedLine Citation:
PMID:  23209159     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The fetal-to-adult hemoglobin switch and silencing of fetal hemoglobin (HbF) have been areas of long-standing interest among hematologists, given the fact that clinical induction of HbF production holds tremendous promise to ameliorate the clinical symptoms of sickle cell disease (SCD) and β-thalassemia. In this article, we discuss historic attempts to induce HbF that have resulted in some therapeutic approaches to manage SCD and β-thalassemia. We then go on to discuss how more recent molecular studies that have identified regulators, including BCL11A, MYB, and KLF1, hold great promise to develop targeted and more effective approaches for HbF induction. We go on to discuss strategies by which such approaches may be developed. Older studies in this field can provide important lessons for future studies aimed at developing more effective strategies for HbF induction, and we therefore chronologically cover the work accomplished as this field has evolved over the course of the past four decades.
Authors:
Vijay G Sankaran; Stuart H Orkin
Related Documents :
24569409 - Hypertension in pregnancy: the most recent findings in pathophysiology, diagnosis and t...
16191599 - Prey attack and predators defend: counterattacking prey trigger parental care in predat...
21353109 - Preconception steroid treatment in infertile women with antithyroid autoimmunity underg...
17241959 - Sap flow estimates of stand transpiration at two slope positions in a japanese cedar fo...
15705849 - Shell composition has no net impact on large-scale evolutionary patterns in mollusks.
1395509 - Serine proteinase inhibitor profiles in the hemolymph of a wide range of insect species.
23219009 - Neonatal and maternal outcomes comparing women undergoing two in vitro fertilization (...
3425229 - Evidence for the luteal source of circulating relaxin in molar pregnancy.
17556829 - Fetus-in-fetu: parasite or neoplasm? a study of two cases.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-3
Journal Detail:
Title:  Cold Spring Harbor perspectives in medicine     Volume:  -     ISSN:  2157-1422     ISO Abbreviation:  Cold Spring Harb Perspect Med     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101571139     Medline TA:  Cold Spring Harb Perspect Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The endoplasmic reticulum-associated degradation pathways of budding yeast.
Next Document:  Synaptic Targets of ?9-Tetrahydrocannabinol in the Central Nervous System.