Document Detail


The G0/G1 switch gene 2 (G0S2): regulating metabolism and beyond.
MedLine Citation:
PMID:  23032787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The G0/G1 switch gene 2 (G0S2) was originally identified in blood mononuclear cells following induced cell cycle progression. Translation of G0S2 results in a small basic protein of 103 amino acids in size. It was initially believed that G0S2 mediates re-entry of cells from the G0 to G1 phase of the cell cycle. Recent studies have begun to reveal the functional aspects of G0S2 and its protein product in various cellular settings. To date the best-known function of G0S2 is its direct inhibitory capacity on the rate-limiting lipolytic enzyme adipose triglyceride lipase (ATGL). Other studies have illustrated key features of G0S2 including sub-cellular localization, expression profiles and regulation, and possible functions in cellular proliferation and differentiation. In this review we present the current knowledge base regarding all facets of G0S2, and pose a variety of questions and hypotheses pertaining to future research directions.
Authors:
Bradlee L Heckmann; Xiaodong Zhang; Xitao Xie; Jun Liu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-09-29
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1831     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-03-14     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  276-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Cell Cycle Proteins / genetics,  physiology*
G0 Phase*
G1 Phase*
Humans
Grant Support
ID/Acronym/Agency:
DK089178/DK/NIDDK NIH HHS; R01 DK089178/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Cell Cycle Proteins; 0/G0S2 protein, human
Comments/Corrections

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