Document Detail

Swine model of coronary restenosis: effect of a second injury.
MedLine Citation:
PMID:  8722857     Owner:  NLM     Status:  MEDLINE    
Looking for a coronary artery restenosis model closer to human pathology, a protocol of balloon injury/reinjury (plaque of dilatation) in swine coronary artery was designed. Pig coronary arteries (n = 24) were dilated for this study: 12, group 1, once (sacrifice at 10.0 +/- 2.2 weeks); 6, group 2, twice at 2-wk intervals (sacrifice at 5.2 +/- 0.2 wk); 6, group 3, twice at 4-wk intervals (sacrifice at 9.3 +/- 1.9 wk). A single overdilatation resulted in an eccentric neointimal hyperplasia representing half of the wall area (group 1, 45.6 +/- 5.1%). In animals (groups 2 and 3) subjected to redilatation, fracture length, ratio of fracture length to internal elastic lamina (IEL) circumference, and neointimal hyperplasia response were similar to those observed in group 1. In group 3, the shape of the lesion appeared more concentric and the fracture of the IEL more fragmented than in group 1. Although this model of injury/reinjury did not lead to more severe intimal hyperplasia, performing a second angioplasty at the same site did lead to a more concentric intimal response, related to multiple fractures of the IEL.
R Bonan; P Paiement; T K Leung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular diagnosis     Volume:  38     ISSN:  0098-6569     ISO Abbreviation:  Cathet Cardiovasc Diagn     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-09-27     Completed Date:  1996-09-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7508512     Medline TA:  Cathet Cardiovasc Diagn     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  44-9     Citation Subset:  IM    
Department of Medicine, Montreal Heart Institute, Quebec, Canada.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary / adverse effects
Constriction, Pathologic / etiology,  pathology
Coronary Disease / etiology,  pathology*
Coronary Vessels / injuries*,  pathology
Disease Models, Animal
Tunica Intima / injuries,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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