| Swimming training beneficial effects in a mice model of nonalcoholic fatty liver disease. | |
| | |
MedLine Citation:
|
PMID: 20869214 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The study aimed to investigate the effect of swimming training in reducing the nonalcoholic fatty liver disease (NAFLD) and associated comorbidities, including the hepatic expression of fatty acid synthesis and peroxisome proliferator receptor activity-alpha. Male C57BL/6 mice were separated into two major groups according to their nutrition and studied during 22 weeks: standard chow (10% fat, SC) or high-fat chow (60% fat, HF), characterizing the sedentary groups SC-Sed and HF-Sed. In the last 10 weeks of the experiment, half of the sedentary groups were submitted to a swimming training with a progressive increase in duration, characterizing the exercised groups: SC-Ex and HF-Ex. At the end of the experiment, considering the findings in the SC-Sed group, HF-Sed group had significantly higher body mass, hyperglycemia, hyperinsulinemia with insulin resistance, hypertrophy of the adipocytes (with inflammatory infiltrate), hypertrophy of the pancreatic islets, dyslipidemia, altered liver enzymes and inflammatory cytokines, and NAFLD with changes in gene expression of hepatic lipogenic and oxidative proteins. The swimming program, even concomitant with the high-fat diet, reduced overweight and all the other worst findings, especially NAFLD. In conclusion, the swimming training can attenuate the morbid effects of a high-fat diet combined with sedentary lifestyle in mice. These data reinforce the notion that swimming exercise can be considered an efficient nonpharmacologic therapy in the treatment of NAFLD, obesity and insulin resistance. |
| | |
Authors:
|
Alini Schultz; Leonardo S Mendonca; Marcia B Aguila; Carlos A Mandarim-de-Lacerda |
Related Documents
:
|
19056644 - Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver ... 19570664 - Short term effects of energy restriction and dietary fat sub-type on weight loss and di... 6575204 - Effect of duration of high fat intake on enhancement of mammary carcinogenesis in rats. 19713964 - Effect of high-fat diet feeding on hypothalamic redox signaling and central blood press... 22445014 - Caecal fermentation characteristics, blood composition and growth of rabbits on substit... 1505704 - A practical intervention programme aimed at decreasing high serum cholesterol levels in... |
Publication Detail:
|
Type: Journal Article Date: 2010-09-23 |
Journal Detail:
|
Title: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Volume: 64 ISSN: 1618-1433 ISO Abbreviation: Exp. Toxicol. Pathol. Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-04-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9208920 Medline TA: Exp Toxicol Pathol Country: Germany |
Other Details:
|
Languages: eng Pagination: 273-82 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier GmbH. All rights reserved. |
Affiliation:
|
Laboratory of Morphometry, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, RJ, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expression of metallothionein cDNA in a freshwater crab, Sinopotamon yangtsekiense, exposed to cadmi...
Next Document: Choline catabolism, ?(54) factor and NtrC are required for the full expression of the Pseudomonas ae...