| Swimming endurance capacity of mice is increased by chronic consumption of medium-chain triglycerides. | |
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MedLine Citation:
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PMID: 7876928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of chronic administration of medium-chain triglycerides (MCT) on swimming endurance (swim capacity) was investigated in male Std ddY mice. The mice were fed a diet containing 80 g MCT + 20 g long-chain triglycerides (LCT)/kg diet for 6 wk; mice fed diet containing 100 g LCT/kg diet were used as controls. After being accustomed to swimming, the mice were subjected to forced swimming every 2 d in the current water pool that we had developed, and the total swimming period until exhaustion was measured. The total swimming period was used as the index of swim capacity. The group fed MCT showed significantly greater swim capacity than the control group (89.5 +/- 2.5 vs. 80.2 +/- 2.0 min). In another experiment, after 4 wk of MCT diet consumption, significantly greater swim capacity was found in untrained mice. The major metabolic consequences of the adaptations of muscle to prolonged MCT administration during endurance training were higher activities of 3-oxo acid CoA-transferase (P < 0.01), citrate synthase (P < 0.1) and malate dehydrogenase (P < 0.1). These findings suggest that increases in the enzyme activities of the tricarboxylic acid cycle and ketone body utilization associated with the chronic administration of an MCT-containing diet enhance swim capacity in mice. |
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Authors:
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T Fushiki; K Matsumoto; K Inoue; T Kawada; E Sugimoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of nutrition Volume: 125 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-04-06 Completed Date: 1995-04-06 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 531-9 Citation Subset: IM |
Affiliation:
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Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dietary Fats / pharmacology* Fatty Acids, Nonesterified / blood Ketone Bodies / blood, metabolism Linoleic Acid Linoleic Acids / blood Liver / metabolism Male Mice Oleic Acid Oleic Acids / blood Physical Endurance / physiology* Swimming Triglycerides / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids, Nonesterified; 0/Ketone Bodies; 0/Linoleic Acids; 0/Oleic Acids; 0/Triglycerides; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid |
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