| Swim-Exercised Mice Show a Decreased Level of Protein O-GlcNAcylation and Expression of O-GlcNAc Transferase in Heart. | |
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MedLine Citation:
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PMID: 21493720 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Swim training exercise in mice leads to cardiac remodeling associated with an improvement in contractile function. Protein O-GlcNAcylation is a post-translational modification of serine and threonine residues capable of altering protein-protein interactions affecting gene transcription, cell signaling pathways and general cell physiology. Increased levels of protein O-GlcNAcylation in the heart have been associated with pathological conditions such as diabetes, ischemia and hypertrophic heart failure. In contrast, the impact of physiological exercise on protein O-GlcNAcylation in the heart is currently unknown. Swim training exercise in mice was associated with the development of a physiological hypertrophy characterized by an improvement in contractile function relative to sedentary mice. General protein O-GlcNAcylation was significantly decreased in swim-exercised mice. This effect was mirrored in the level of O-GlcNAcylation of individual proteins such as SP1. The decrease in protein O-GlcNAcylation was associated with a decrease in the expression of O-GlcNAc transferase (OGT) and GFAT2 mRNA. O-GlcNAcase (OGA) activity was actually lower in swim trained than sedentary hearts, suggesting that it did not contribute to the decreased protein O-GlcNAcylation. Thus, it appears that exercise-induced physiological hypertrophy is associated with a decrease in protein O-GlcNAcylation, which could potentially contribute to changes in gene expression and other physiological changes associated with exercise. |
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Authors:
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Darrell D Belke |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-14 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Calgary. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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