| Swelling and erosion properties of hydroxypropylmethylcellulose (Hypromellose) matrices--influence of agitation rate and dissolution medium composition. | |
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MedLine Citation:
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PMID: 15234802 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of dissolution medium variables, such as medium composition, ionic strength and agitation rate, on the swelling and erosion of Hypromellose (hydroxypropylmethylcellulose, HPMC) matrices of different molecular weights was examined. Swelling and erosion of HPMC polymers was determined by measuring the wet and subsequent dry weights of matrices. It was possible to describe the rate of dissolution medium uptake in terms of a square root relationship and the erosion of the polymer in terms of the cube root law. The extent of swelling increased with increasing molecular weight, and decreased with increasing agitation rate. The erosion rate was seen to increase with decrease in polymer molecular weight, with a decrease in ionic strength and with increasing agitation rate. The sensitivity of polymer erosion to the degree of agitation may influence the ability of these polymers to give reproducible, agitation-independent release, compared to more rigid non-eroding matrix materials, in the complex hydrodynamic environment of the gastrointestinal tract. |
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Authors:
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Nicole Kavanagh; Owen I Corrigan |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 279 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-07-05 Completed Date: 2004-11-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 141-52 Citation Subset: IM |
Affiliation:
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School of Pharmacy, Trinity College, University of Dublin, Dublin 2, Ireland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Hydrogen-Ion Concentration Methylcellulose / analogs & derivatives, chemistry* Molecular Weight Solubility Solvents / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Solvents; 8063-82-9/hypromellose; 9004-67-5/Methylcellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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