| Swelling behaviour of pH-sensitive crosslinked poly(vinyl acetate co-acrylic acid) hydrogels for site specific drug delivery. | |
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MedLine Citation:
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PMID: 16414825 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The present work was undertaken to combine nonionic vinyl acetate (VAC) with anionic acrylic acid (AA) or methacrylic acid (MAA) monomers in the presence of ethylen glycol dimethacrylate (EGDMA) as cross-linking agent through radical polymerization. Poly(vinyl acetate-co-acrylic acid) VAC/AA 50:50 to 100:0 six samples and poly(vinyl acetate-co-methacrylic acid) VAC/MAA one sample were prepared. All the samples were used for swelling studies. High swelling occurred at above pH 5.5 through chain relaxation. It was observed that swelling in VAC/MAA was lower than VAC/AA copolymers. The lower swelling in VAC/MAA copolymer is due to the presence of hydrophobic methyl group and higher pKa value of this copolymer. |
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Authors:
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N M Ranjha |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pakistan journal of pharmaceutical sciences Volume: 12 ISSN: 1011-601X ISO Abbreviation: Pak J Pharm Sci Publication Date: 1999 Jan |
Date Detail:
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Created Date: 2006-01-17 Completed Date: 2006-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426356 Medline TA: Pak J Pharm Sci Country: Pakistan |
Other Details:
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Languages: eng Pagination: 33-41 Citation Subset: - |
Affiliation:
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Department of Pharmacy Bahauddin, Zakariya University, Multan, 60800, Pakistan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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