Document Detail


Swelling behavior and release properties of pH-sensitive hydrogels based on methacrylic derivatives.
MedLine Citation:
PMID:  17878110     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study is to develop novel intestinal-specific drug delivery systems with pH sensitive swelling and drug release properties. Methacrylic-type polymeric prodrugs were synthesized by free radical copolymerization of methacrylic acid, poly(ethyleneglycol monomethyl ether methacrylate) and a methacrylic derivative of N-(4-hydroxyphenyl)-2-(4-methoxyphenyl) acetamide in the presence of ethylene glycol dimethacrylate as crosslinking agent. The effect of copolymer composition on the swelling behavior and hydrolytic degradation were studied in simulated gastric (SGF, pH 1.2) and intestinal fluids (SIF, pH 7.0). The dynamic swelling behavior of these hydrogels was investigated to determine the mechanism of water transport through these hydrogels. The mechanism of water transport through the gels was significantly affected by the pH of the swelling medium and became more relaxation-controlled in a swelling medium of pH 7.0. The swelling and hydrolytic behaviors of hydrogels were dependent on the content of methacrylic acid (MAA) groups and caused a decrease and increase in gel swelling in SGF and SIF, respectively. Drug release studies showed that the increasing content of MAA in the copolymer enhances hydrolysis in SIF. These results suggest that pH-sensitive systems could be useful for preparation of a muccoadhesive system and controlled release of N-(4-hydroxyphenyl)-2-(4-methoxyphenyl) acetamide.
Authors:
Tahar Bartil; Mahmoud Bounekhel; Calberg Cedric; Robert Jeerome
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pharmaceutica (Zagreb, Croatia)     Volume:  57     ISSN:  1330-0075     ISO Abbreviation:  Acta Pharm     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-19     Completed Date:  2008-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9303678     Medline TA:  Acta Pharm     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  301-14     Citation Subset:  IM    
Affiliation:
Département de génie des procédés Faculté des sciences de l'ingénieur, Université ferhat Abbas, SETIF (19000), Algérie. tbartil2002@yahoo.fr
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MeSH Terms
Descriptor/Qualifier:
Absorption
Acetamides / administration & dosage,  chemistry,  pharmacokinetics
Acetanilides / chemistry
Algorithms
Drug Delivery Systems / methods
Gastric Juice / metabolism
Gastrointestinal Agents / administration & dosage,  chemistry,  pharmacokinetics*
Hydrogels / chemistry*
Hydrogen-Ion Concentration
Methacrylates / chemistry*
Molecular Structure
Phenols / chemistry
Polyethylene Glycols / chemistry
Technology, Pharmaceutical / methods
Time Factors
Water / chemistry*
Chemical
Reg. No./Substance:
0/Acetamides; 0/Acetanilides; 0/Gastrointestinal Agents; 0/Hydrogels; 0/Methacrylates; 0/N-(4-hydroxyphenyl)-2-(4-methoxyphenyl)acetamide; 0/Phenols; 0/Polyethylene Glycols; 0/poly(methacrylic acid-co-ethyleneglycol monomethyl ether-co-N-(4-methacryloyloxyphenyl)-2-(4-methoxyphenyl)acetamide); 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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