Document Detail

Sweetened carbonated drinks do not alter upper digestive tract physiology in healthy subjects.
MedLine Citation:
PMID:  18373521     Owner:  NLM     Status:  MEDLINE    
Sweetened carbonated beverages are widely consumed, which has fuelled several conflicting opinions about their effects on upper digestive tract functions. We aimed to evaluate the effect of sweetened carbonated drinks, consumed with a standard meal, on gastro-oesophageal reflux, gastric emptying and gallbladder contraction and postmeal sensations in healthy subjects. Thirteen healthy volunteers (seven women, six males; median age 22 years) were tested following the intake of 300 mL sweetened water containing increasing concentrations of carbon dioxide (seven subjects), and of 300 mL sweetened commercial flavoured drink with and without carbon dioxide (six subjects). Gastro-oesophageal reflux, gastric emptying and gallbladder contraction were studied by pH-impedance, octanoic acid breath test and ultrasound respectively. Gastro-oesophageal refluxes were significantly increased 1 h after meal with both water and commercial beverages; only sweetened water without carbon dioxide determined a persistently increasing number of refluxes 2 h postmeal. No differences were found for gastric emptying, gallbladder contraction or postmeal symptoms with any of the beverages tested. This study shows that 300 mL of sweetened carbonated beverage with different levels of carbonation or a commercial soft drink do not modify the physiology of the upper digestive tract.
R Cuomo; M F Savarese; G Sarnelli; G Vollono; A Rocco; P Coccoli; C Cirillo; L Asciore; G Nardone; M Buyckx
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-26
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  20     ISSN:  1365-2982     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-18     Completed Date:  2008-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  780-9     Citation Subset:  IM    
Gastroenterology Unit, Department of Clinical and Experimental Medicine, University of Naples, Naples, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Breath Tests
Carbonated Beverages*
Gallbladder / physiology
Gastric Emptying / physiology
Gastroesophageal Reflux
Postprandial Period
Sweetening Agents / metabolism*
Upper Gastrointestinal Tract / physiology*
Reg. No./Substance:
0/Sweetening Agents; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Electrophysiological and morphological properties of submucosal neurons in the mouse distal colon.
Next Document:  Characterization of ExsA and of ExsA-dependent promoters required for expression of the Pseudomonas ...