Document Detail


Sweetened-fat intake sensitizes gamma-aminobutyric acid-mediated feeding responses elicited from the nucleus accumbens shell.
MedLine Citation:
PMID:  23312563     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is much interest in exploring whether reward-driven feeding can produce druglike plasticity in the brain. The gamma-aminobutyric acid (GABA) system in the nucleus accumbens (Acb) shell, which modulates hypothalamic feeding systems, is well placed to "usurp" homeostatic control of feeding. Nevertheless, it is unknown whether feeding-induced neuroadaptations occur in this system.
METHODS: Separate groups of ad libitum-maintained rats were exposed to daily bouts of sweetened-fat intake, predator stress, or intra-Acb shell infusions of either d-amphetamine (2 or 10 μg) or the μ-opioid agonist D-[Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO, 2.5 μg), then challenged with intra-Acb shell infusion of the GABAA agonist, muscimol (10 ng).
RESULTS: Exposure to sweetened fat robustly sensitized muscimol-induced feeding. Sensitization was present 1 week after cessation of the palatable feeding regimen but had abated by 2 weeks. Rats exposed to sweetened fat did not show an altered feeding response to food deprivation. Repeated intra-Acb shell infusions of DAMGO (2.5 μg) also sensitized intra-Acb shell muscimol-driven feeding. However, neither repeated intra-Acb shell d-amphetamine infusions (2 or 10 μg) nor intermittent exposure to an aversive stimulus (predator stress) altered sensitivity to muscimol.
CONCLUSIONS: Palatable feeding engenders hypersensitivity of Acb shell GABA responses; this effect may involve feeding-induced release of opioid peptides. Heightened arousal, aversive experiences, or increased catecholamine transmission alone are insufficient to produce the effect, and a hunger-induced feeding drive is insufficient to reveal the effect. These findings reveal a novel type of food-induced neuroadaptation within the Acb; possible implications for understanding crossover effects between food reward and drug reward are discussed.
Authors:
Sarah Newman; Lindsay Pascal; Ken Sadeghian; Brian A Baldo
Related Documents :
23913733 - Effect of insulin sensitivity on corticolimbic responses to food picture in women with ...
22993653 - Chewing side preference in first and all mastication cycles for hard and soft morsels.
18631413 - Analysis of the impact of fortified food consumption on overall dietary quality in iris...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-08
Journal Detail:
Title:  Biological psychiatry     Volume:  73     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-16     Completed Date:  2013-10-21     Revised Date:  2014-01-16    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  843-50     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Dextroamphetamine / pharmacology
Dietary Fats / pharmacology*
Dopamine Uptake Inhibitors / pharmacology
Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / pharmacology
Feeding Behavior / drug effects*
GABA-A Receptor Agonists / pharmacology
Male
Muscimol / pharmacology
Nucleus Accumbens / drug effects*
Rats
Rats, Sprague-Dawley
Stress, Psychological / physiopathology*
Sucrose / pharmacology*
Sweetening Agents / pharmacology
Grant Support
ID/Acronym/Agency:
DA 009311/DA/NIDA NIH HHS; MH 074723/MH/NIMH NIH HHS; R01 DA009311/DA/NIDA NIH HHS; R01 MH074723/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Dopamine Uptake Inhibitors; 0/GABA-A Receptor Agonists; 0/Sweetening Agents; 100929-53-1/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; 2763-96-4/Muscimol; 57-50-1/Sucrose; TZ47U051FI/Dextroamphetamine
Comments/Corrections
Comment In:
Biol Psychiatry. 2013 Oct 1;74(7):e11   [PMID:  23726509 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in...
Next Document:  Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces t...