| Sweet liking and high novelty seeking: Independent phenotypes associated with alcohol-related problems. | |
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MedLine Citation:
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PMID: 20663854 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIM: We tested the hypothesis that high novelty seeking (NS; a trait that promotes experimentation) and hedonic response to sweet taste (a trait that may reflect processing of hedonic stimuli) act independently to increase the risk for having alcohol-related problems in young adults. METHODS: The study was conducted in 158 healthy subjects (age 20-25 years) with no lifetime history of alcohol and/or drug abuse/dependence. NS was evaluated using the Tridimensional Personality Questionnaire. Pleasurable response to sweet taste was tested, using a sweet taste test to identify sweet likers (SL; those preferring the strongest offered sucrose solution) and sweet dislikers (SDL; those preferring weaker sucrose solutions). RESULTS: NS score, but not SL/SDL status, was positively correlated with drinks per month (P = 0.0054) and drinks per drinking day (P = 0.021). When tested individually, both NS and SL/SDL status predict having alcohol-related problems (NS: odds ratio [OR] = 5.3, P = 0.0016 and SL/SDL: OR = 5.8, P = 0.0001) with an OR similar to positive family history of alcoholism status (OR = 5.7, P = 0.0007). The combination of SL status and high NS score (greater than gender-specific 70th percentile) greatly increased the estimated odds of having alcohol-related problems (OR 27.5, P < 0.0001). CONCLUSIONS: These results support the hypothesis that high NS and SL phenotypes are independently associated with risk of alcohol-related problems. The combination of both phenotypes greatly increases the likelihood of alcohol-related problems. Although confirmation is necessary, this suggests that these phenotypes could contribute to improved methods to assess risk for alcohol-related problems and provide additional insight into processes underlying progression to alcohol-related problems. |
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Authors:
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Leslie A Lange; Alexey B Kampov-Polevoy; James C Garbutt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-27 |
Journal Detail:
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Title: Alcohol and alcoholism (Oxford, Oxfordshire) Volume: 45 ISSN: 1464-3502 ISO Abbreviation: Alcohol Alcohol. Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-09-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8310684 Medline TA: Alcohol Alcohol Country: England |
Other Details:
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Languages: eng Pagination: 431-6 Citation Subset: IM |
Affiliation:
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Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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