Document Detail

Swedish Trial in Old Patients with Hypertension (STOP-Hypertension) analyses performed up to 1992.
MedLine Citation:
PMID:  7903578     Owner:  NLM     Status:  MEDLINE    
Hypertension is increasingly common with advancing age and a risk factor for all kinds of cardiovascular complications. Moreover, cardiovascular disease is a major cause of morbidity and mortality in the elderly. The Swedish Trial in Old Patients with Hypertension (STOP-Hypertension) was set up by the Swedish Hypertension Society to investigate the value of antihypertensive treatment in the elderly. In this placebo controlled randomised prospective study 1,627 men and women aged 70-84 years with a supine blood pressure > or = 180/105 mmHg (and/or) but not isolated systolic hypertension participated. Three beta-blockers and one diuretic were used as blood pressure lowering agents and the average follow-up in the study was 25 months (3,390 patient-years). Administration of active antihypertensive therapy, reduced supine blood pressure from 195/102 mmHg to 167/87 mmHg at longest follow-up in comparison with placebo. A majority of the patients needed combined treatment to reach the goal blood pressure (160/95 mmHg). Associated with a fall in blood pressure were significant reductions in all cardiovascular primary endpoints (-40%, p = 0.0031), in fatal and non-fatal stroke (-47%, p = 0.0081) and in total mortality (-43%, p = 0.0079). In addition to the substantial effects on primary endpoints active treatment also showed clinically relevant effects on secondary endpoints (e.g. heart failure). The impact on cardiovascular morbidity and mortality with antihypertensive treatment in this elderly cohort was greater than previously seen in middle-aged hypertensive patients, with maintained tolerability and a favourable cost-effectiveness ratio. Finally, women benefited from treatment at least as much as men.
B Dahlöf; L Hansson; L H Lindholm; B Scherstén; T Ekbom; P O Wester
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  15     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-03     Completed Date:  1994-02-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  925-39     Citation Subset:  IM    
Department of Medicine, University of Göteborg, Ostra Hospital.
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MeSH Terms
Adrenergic beta-Antagonists / adverse effects,  therapeutic use*
Aged, 80 and over
Blood Pressure / drug effects
Diuretics / adverse effects,  therapeutic use*
Heart Rate / drug effects
Hypertension / drug therapy*,  physiopathology
Prospective Studies
Sex Factors
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Diuretics

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