| Sweat test in patients with glucose-6-phosphate-1-dehydrogenase deficiency. | |
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MedLine Citation:
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PMID: 18456694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A false-positive sweat test in patients with deficiency of glucose-6-phosphate-1-dehydrogenase (EC 1.1.1.49; G6PD) is repeatedly reported. METHODS: Sweat chloride or conductivity was measured in 11 patients with G6PD deficiency. RESULTS: Mean (SD) chloride level (n = 8, median age 9.2 years, range 1.9-48.5) was 18.8 (9.6 mmol/l) and, mean (SD) sodium level was 26.0 (10.0 mmol/l), respectively, and mean (SD) conductivity (n = 3, median age 6.6 years, range 1.9-40.5) was 34.3 (6.5 mmol/l). CONCLUSION: In sweat of 11 patients with G6PD deficiency we did not find any abnormality. The reason for alleged false-positive sweat test in patients with G6PD deficiency is not known and we were unable to identify any original reference. It appears that tables of putative false-positive sweat tests in several disease states have been directly "copied and pasted" from one paper or textbook to another without verifying the original literature, a phenomenon one can call "chain citation". |
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Authors:
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C Casaulta; A Stirnimann; M H Schoeni; J Barben |
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Publication Detail:
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Type: Journal Article Date: 2008-05-02 |
Journal Detail:
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Title: Archives of disease in childhood Volume: 93 ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-23 Completed Date: 2008-10-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: England |
Other Details:
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Languages: eng Pagination: 878-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Paediatrics, University of Berne, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child Child, Preschool Chlorides / analysis Cystic Fibrosis / diagnosis Diagnosis, Differential Electric Conductivity False Positive Reactions Female Glucosephosphate Dehydrogenase Deficiency / diagnosis*, metabolism Humans Infant Male Middle Aged Sodium / analysis Sweat / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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