Document Detail

Sweat test in patients with glucose-6-phosphate-1-dehydrogenase deficiency.
MedLine Citation:
PMID:  18456694     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A false-positive sweat test in patients with deficiency of glucose-6-phosphate-1-dehydrogenase (EC; G6PD) is repeatedly reported. METHODS: Sweat chloride or conductivity was measured in 11 patients with G6PD deficiency. RESULTS: Mean (SD) chloride level (n = 8, median age 9.2 years, range 1.9-48.5) was 18.8 (9.6 mmol/l) and, mean (SD) sodium level was 26.0 (10.0 mmol/l), respectively, and mean (SD) conductivity (n = 3, median age 6.6 years, range 1.9-40.5) was 34.3 (6.5 mmol/l). CONCLUSION: In sweat of 11 patients with G6PD deficiency we did not find any abnormality. The reason for alleged false-positive sweat test in patients with G6PD deficiency is not known and we were unable to identify any original reference. It appears that tables of putative false-positive sweat tests in several disease states have been directly "copied and pasted" from one paper or textbook to another without verifying the original literature, a phenomenon one can call "chain citation".
C Casaulta; A Stirnimann; M H Schoeni; J Barben
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Publication Detail:
Type:  Journal Article     Date:  2008-05-02
Journal Detail:
Title:  Archives of disease in childhood     Volume:  93     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-23     Completed Date:  2008-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  England    
Other Details:
Languages:  eng     Pagination:  878-9     Citation Subset:  AIM; IM    
Department of Paediatrics, University of Berne, Switzerland.
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MeSH Terms
Child, Preschool
Chlorides / analysis
Cystic Fibrosis / diagnosis
Diagnosis, Differential
Electric Conductivity
False Positive Reactions
Glucosephosphate Dehydrogenase Deficiency / diagnosis*,  metabolism
Middle Aged
Sodium / analysis
Sweat / chemistry*
Reg. No./Substance:
0/Chlorides; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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