Document Detail

Sweat analysis following pressure ischaemia in a group of debilitated subjects.
MedLine Citation:
PMID:  9239623     Owner:  NLM     Status:  MEDLINE    
This article examines the application of a simple technique for the collection of sweat to the investigation of tissue metabolites in 11 debilitated subjects attending a rehabilitation unit. It is applicable to subjects with a range of clinical conditions. Sweat was collected at the sacrum with the subjects either seated in a wheelchair or lying in bed, which was representative of their usual daily routine. The tissues could be loaded during sweat collection by sacral support in either of these positions. Collections were made for about 10 hours and interface pressures were recorded on at least two occasions. After the prescribed period, the sweat pads were removed and a quantitative analysis of a range of metabolites was performed. Metabolite concentrations may reflect local tissue viability and responses to loading. In unloaded tissues the metabolite concentrations were similar to those observed in nondisabled subjects in an earlier study. During prolonged loading at relatively low levels of pressure, there was elevation in the levels of some metabolites; for example 39 and 28% increases for lactate and urea respectively. Successive measurements on an individual over a period of months showed variations, which were small compared to those observed in either groups of nondisabled or debilitated subjects. These observations suggest that the technique may be best applied in clinical practice to monitor sequential changes in individual subjects.
A Polliack; R Taylor; D Bader
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of rehabilitation research and development     Volume:  34     ISSN:  0748-7711     ISO Abbreviation:  J Rehabil Res Dev     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-11     Completed Date:  1997-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8410047     Medline TA:  J Rehabil Res Dev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  IM; S    
Oxford Orthopaedic Engineering Centre, University of Oxford, UK.
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MeSH Terms
Circadian Rhythm
Disabled Persons*
Feasibility Studies
Middle Aged
Monitoring, Physiologic
Pressure Ulcer / metabolism*
Reproducibility of Results
Specimen Handling / methods*
Sweat / chemistry*,  metabolism*

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