Document Detail

Swallowing dysfunction in Wilson's disease: a scintigraphic study.
MedLine Citation:
PMID:  18036136     Owner:  NLM     Status:  MEDLINE    
Although dysphagia is a common complaint of patients with Wilson's disease (WD) and pneumonia is an important cause of death in these patients, swallowing function remains an underinvestigated field in this condition. The aim of this study was to characterize swallowing dynamics in WD patients. Eight WD patients and 15 age-matched controls underwent scintigraphic evaluation of oral and pharyngeal deglutition. Patients had significantly slower oral transit (P = 0.008) and a greater percentage of oral residue (P = 0.006) when compared to controls. Two of eight patients were free of neurological symptoms at time of examination. Impaired oropharyngeal function was found in patients without dysphagia and without neurological symptoms. Our findings indicate that WD may present with objective swallowing dysfunction, even in the absence of neurological manifestations. Further studies are necessary to investigate the impact of this dysfunction on morbidity and mortality in WD.
F P da Silva-Júnior; A E A B Carrasco; A M da Silva Mendes; A J T Lopes; M A Nobre E Souza; V M S de Bruin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-23
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  20     ISSN:  1365-2982     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-28     Completed Date:  2008-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  285-90     Citation Subset:  IM    
Department of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
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MeSH Terms
Deglutition Disorders / diagnosis,  etiology*
Hepatolenticular Degeneration / complications*,  physiopathology
Middle Aged
Radionuclide Imaging

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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