| Sutureless small bowel anastomoses: experimental study in pigs. | |
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MedLine Citation:
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PMID: 10069636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate a new technique for experimental anastomosis with fibrin glue, and to compare the results with those of stapled and one-layer sutured anastomosis. DESIGN: Open laboratory study. SETTING: Teaching hospital, Sweden. ANIMALS: Ten Swedish domestic pigs. INTERVENTIONS: Each pig had three anastomoses made in the small bowel, one by each technique. The pigs were killed on the 4th postoperative day. MAIN OUTCOME MEASURES: Blood flow, collagen concentration, anastomotic index, breaking strength, thickness of bowel wall, and histological appearance. RESULTS: Two pigs died postoperatively, leaving 8 for analysis. The blood flow at each anastomotic site studied by the microsphere technique was similar irrespective of the type of anastomosis (p = 0.3), as was anastomotic collagen concentration (p = 0.09). The anastomotic index, however, was significantly higher in the stapled than in the glued or sutured ones (p = 0.03). The glued anastomosis was the weakest, being only one fifth the strength of the stapled and one third the strength of the sutured anastomosis. There was no sign of rejection of the glue (of human origin) on histological examination. Glued and stapled anastomoses showed signs of mild inflammation, which did not reach the intensity of that around the sutured anastomoses. CONCLUSION: It is possible to make a sutureless anastomosis that does not leak with a modified stapler using fibrin glue instead of staples, but the anastomosis has considerably lower breaking strength than either stapled or sutured anastomoses. |
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Authors:
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T L Zilling; O Jansson; B S Walther; A Ottosson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The European journal of surgery = Acta chirurgica Volume: 165 ISSN: 1102-4151 ISO Abbreviation: Eur J Surg Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-04-22 Completed Date: 1999-04-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105264 Medline TA: Eur J Surg Country: NORWAY |
Other Details:
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Languages: eng Pagination: 61-8 Citation Subset: IM |
Affiliation:
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Department of Surgery and Forensic Medicine, Lund University Hospital, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anastomosis, Surgical
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methods* Animals Evaluation Studies as Topic Fibrin Tissue Adhesive / therapeutic use* Intestine, Small / surgery* Surgical Stapling* Suture Techniques* Swine Tissue Adhesives / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Tissue Adhesive; 0/Tissue Adhesives |
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