| Sustained visual recovery after treatment with intrathecal methotrexate in a case of optic neuropathy caused by chronic lymphocytic leukemia. | |
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MedLine Citation:
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PMID: 15937434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 68-year-old woman with chronic lymphocytic leukemia (CLL) had acute optic neuropathy associated with cerebrospinal fluid evidence of meningeal spread of CLL. There was no evidence of a hematologic relapse. After undergoing four weekly doses of intrathecal methotrexate, vision improved dramatically and spinal fluid became normal. Four years later, she has near normal vision in the affected eye and remains in hematologic remission. This is the first reported case of successful treatment of optic neuropathy in CLL with intrathecal methotrexate alone. |
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Authors:
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Lizette Mowatt; Tim Matthews; Ioanne Anderson |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society Volume: 25 ISSN: 1070-8022 ISO Abbreviation: J Neuroophthalmol Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-06 Completed Date: 2005-07-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9431308 Medline TA: J Neuroophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 113-5 Citation Subset: IM |
Affiliation:
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Sandwell and West Birmingham NHS Trust, Birmingham and Midland Eye Center, Birmingham, England. lillenea@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antimetabolites, Antineoplastic / administration & dosage, therapeutic use* Female Humans Injections, Spinal Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*, physiopathology Methotrexate / administration & dosage, therapeutic use* Optic Nerve Neoplasms / drug therapy*, physiopathology Recovery of Function Visual Acuity / physiology* Visual Fields |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites, Antineoplastic; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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