Document Detail

Sustained visual recovery after treatment with intrathecal methotrexate in a case of optic neuropathy caused by chronic lymphocytic leukemia.
MedLine Citation:
PMID:  15937434     Owner:  NLM     Status:  MEDLINE    
A 68-year-old woman with chronic lymphocytic leukemia (CLL) had acute optic neuropathy associated with cerebrospinal fluid evidence of meningeal spread of CLL. There was no evidence of a hematologic relapse. After undergoing four weekly doses of intrathecal methotrexate, vision improved dramatically and spinal fluid became normal. Four years later, she has near normal vision in the affected eye and remains in hematologic remission. This is the first reported case of successful treatment of optic neuropathy in CLL with intrathecal methotrexate alone.
Lizette Mowatt; Tim Matthews; Ioanne Anderson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society     Volume:  25     ISSN:  1070-8022     ISO Abbreviation:  J Neuroophthalmol     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-06     Completed Date:  2005-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9431308     Medline TA:  J Neuroophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-5     Citation Subset:  IM    
Sandwell and West Birmingham NHS Trust, Birmingham and Midland Eye Center, Birmingham, England.
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MeSH Terms
Antimetabolites, Antineoplastic / administration & dosage,  therapeutic use*
Injections, Spinal
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*,  physiopathology
Methotrexate / administration & dosage,  therapeutic use*
Optic Nerve Neoplasms / drug therapy*,  physiopathology
Recovery of Function
Visual Acuity / physiology*
Visual Fields
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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