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Sustained torpidity following multi-dose administration of 3-iodothyronamine in mice.
MedLine Citation:
PMID:  21140443     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Despite significant medical benefits as in space exploration or emergency care, prolonged torpidity of non-hibernator mammals remains unexplored to date. Here, we report that male ICR mice could sustain two separate 2-day torpor bouts and maintain body temperature of 28 - 33°C following repeated treatments of 3-iodothyronamine (T(1)AM), a natural derivative of thyroid hormone. A 1-day interbout arousal period, adopted to mimic the behavior of true hibernators, seemed critical for the subjects to restore physiological homeostasis. Molecular studies of neuron-specific enolase, S100 calcium binding protein B and heat shock protein 72 suggested that the brain maintains functional and cytoprotective activities during sustained torpidity. Together, the results of this study propose a practical protocol using a torpor-arousal cycle that can be applied to the extreme medical situations. © 2010 Wiley-Liss, Inc.
Authors:
Hyunwoo Ju; Hyekyoung So; Kyungbong Ha; Kyoungsook Park; Ju-Woon Lee; Chan-Moon Chung; Inho Choi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-7
Journal Detail:
Title:  Journal of cellular physiology     Volume:  -     ISSN:  1097-4652     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Biological Science and Technology, College of Science and Technology, Yonsei University, Wonju, Gangwon-Do, Republic of Korea.
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