Document Detail

Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver.
MedLine Citation:
PMID:  22504828     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: In normal liver and over a broad age range, cholangiocytes have longer telomeres than all other intrahepatic lineages. Age-related telomere length decline is restricted to Kupffer cells and stellate cells.
Suman Verma; Phaedra Tachtatzis; Sue Penrhyn-Lowe; Cinzia Scarpini; Diana Jurk; Thomas Von Zglinicki; Nick Coleman; Graeme J M Alexander
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-27
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  56     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-05     Completed Date:  2013-01-17     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1510-20     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
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MeSH Terms
Aging / genetics*
Bile Ducts / cytology*,  physiology
Cell Aging / genetics*
Cells, Cultured
Child, Preschool
Hepatocytes / metabolism,  physiology*
In Situ Hybridization, Fluorescence
Kupffer Cells / cytology,  physiology
Liver / pathology*
Middle Aged
Real-Time Polymerase Chain Reaction / methods
Reference Values
Reproducibility of Results
Risk Assessment
Sampling Studies
Sensitivity and Specificity
Telomere / genetics*,  physiology
Telomere Shortening / genetics
Young Adult
Grant Support
G0900686//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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