Document Detail


Sustained strenuous exercise increases intestinal permeability in racing Alaskan sled dogs.
MedLine Citation:
PMID:  15715045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed gastric and intestinal permeability and performed gastroscopy to evaluate the effects of sustained strenuous exercise on the gastrointestinal tract in racing sled dogs. Three teams of racing Alaskan sled dogs were examined approximately 1 week before and 24 hours after the 2003 Iditarod sled dog race (1,100 miles in 10 days). Each examination consisted of the administration of a solution of sucrose, lactulose, and rhamnose to evaluate gastric and intestinal permeability, as well as gastroscopy to visually inspect the gastric mucosa. Of the 54 dogs examined before the race, 16 completed the course and contributed data to the analysis. Sustained strenuous exercise was associated with an increased frequency of gastric erosions or ulcerations seen endoscopically (0% prerace versus 61% postrace). A significant postrace increase occurred in the median lactulose to rhamnose ratio in both serum and urine (0.11 versus 0.165, P = .0363; 0.11 versus 0.165, P = .0090, respectively). No significant differences were found in median serum or urinary sucrose concentrations when pre- and postrace values were compared. No correlation was found between visible gastric lesions and the concentration of sucrose in serum or urine samples obtained 4-5 hours after administration of the sugar solutions. We conclude that sustained strenuous exercise is associated with increased intestinal permeability, but the sucrose permeability test as we performed it did not correlate with visible gastric lesions.
Authors:
Michael S Davis; Michael D Willard; Katherine K Williamson; Jörg M Steiner; David A Williams
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  19     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2005-02-17     Completed Date:  2005-03-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-9     Citation Subset:  IM    
Affiliation:
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA. msdavis@okstate.edu
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MeSH Terms
Descriptor/Qualifier:
Alaska
Animals
Chromatography, High Pressure Liquid / veterinary
Dog Diseases / diagnosis,  metabolism
Dogs
Gastric Mucosa / metabolism
Gastroscopes / veterinary
Intestine, Small / metabolism*
Lactulose / metabolism
Permeability
Physical Conditioning, Animal / physiology*
Physical Exertion / physiology*
Rhamnose / metabolism
Stomach Ulcer / diagnosis,  metabolism,  veterinary
Sucrose / metabolism*
Chemical
Reg. No./Substance:
10485-94-6/Rhamnose; 4618-18-2/Lactulose; 57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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