Document Detail

Sustained relief of dystonia following cessation of deep brain stimulation.
MedLine Citation:
PMID:  17674409     Owner:  NLM     Status:  MEDLINE    
We describe the unusual clinical course of a patient with cranial dystonia (i.e., Meige syndrome) and additional upper limb involvement, who developed sustained relief of motor symptoms following cessation of a prolonged course of bilateral pallidal deep brain stimulation (DBS). Early response to therapy proved titratable and reversible; however, the patient gained independence from DBS in the fifth postoperative year and has since been more than a year without treatment or exacerbation of motor symptoms. Among the potential explanations for these neurological benefits lies the intriguing possibility that DBS therapy may have the capacity to induce plastic change that lessens or obviates the need for further treatment in susceptible patients.
Matthew O Hebb; Paula Chiasson; Anthony E Lang; Robert M Brownstone; Ivar Mendez
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  22     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2008-03-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1958-62     Citation Subset:  IM    
Copyright Information:
2007 Movement Disorder Society
Division of Neurosurgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.
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MeSH Terms
Deep Brain Stimulation*
Dominance, Cerebral / physiology
Electrodes, Implanted
Follow-Up Studies
Globus Pallidus / physiopathology
Long-Term Care
Magnetic Resonance Imaging
Meige Syndrome / diagnosis,  physiopathology,  therapy*
Middle Aged
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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