| Sustained-release erythropoietin ameliorates cardiac function in infarcted rat-heart without inducing polycythemia. | |
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MedLine Citation:
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PMID: 17186991 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The usefulness of sustained-release erythropoietin for improving left ventricular (LV) function without polycythemia was evaluated in a rat chronic myocardial infarction model. METHODS AND RESULTS: Four weeks after left coronary artery ligation, 50 Sprague-Dawley rats were assigned to 5 groups (n=10, each). Control group had a gelatin sheet (20x20 mm) containing saline applied to the infarct area, whereas the 4 treatment groups had gelatin sheets incorporating erythropoietin 0.1 U, 1 U, 10 U and 100 U, respectively. Endpoint measurements performed at 8 weeks after the coronary ligation revealed that the fractional area change was larger for erythropoietin 1 U and 10 U than in the other 3 groups. The LV end-systolic elastance and the time constant of isovolumic relaxation were better for erythropoietin 1 U and 10 U than in the other 3 groups. The density of vessels larger than 50 microm in diameter was the highest in the erythropoietin 1 U group. The number of red blood cells was significantly increased in groups receiving erythropoietin 10 U and 100 U. CONCLUSIONS: Gelatin hydrogel sheets incorporating 1 U erythropoietin improved LV function without inducing polycythemia in a rat chronic myocardial infarction model. |
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Authors:
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Xue Lin; Masatoshi Fujita; Naoki Kanemitsu; Yu Kimura; Keiichi Tambara; Goditha U Premaratne; Atsushi Nagasawa; Tadashi Ikeda; Yasuhiko Tabata; Masashi Komeda |
Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 71 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-25 Completed Date: 2007-02-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 132-7 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Delayed-Action Preparations Disease Models, Animal Dose-Response Relationship, Drug Echocardiography Erythropoietin / administration & dosage, pharmacology, therapeutic use* Gelatin Heart / drug effects, physiology* Male Myocardial Infarction / drug therapy*, physiopathology Neovascularization, Physiologic / drug effects Polycythemia / physiopathology, prevention & control* Rats Rats, Sprague-Dawley Ventricular Dysfunction, Left / drug therapy, physiopathology Ventricular Remodeling / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 11096-26-7/Erythropoietin; 9000-70-8/Gelatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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