Document Detail


Sustained release characteristics of rifampin-loaded microsphere formulations in nonhuman primates.
MedLine Citation:
PMID:  15371105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Controlled release rifampin-loaded microspheres were evaluated for the first time in nonhuman primates. Animals received either 2.0 g of a large formulation (10-150 microm, 23 wt% rifampin) injected subcutaneously at Day 0 (118-139 mg rifampin/kg), 4.0 g of a small formulation (1-10 microm, 5.8 wt% rifampin) administered intravenously in 2.0 g doses on Day 0 and 7 (62.7-72.5 mg rifampin/kg), or a combination of small and large microspheres (169-210 mg rifampin/kg). Extended rifampin release was observed up to 48 days. Average rifampin concentrations remaining in the liver, lung, and spleen at 30 days were 14.03, 4.09, and 1.98 microg/g tissue, respectively.
Authors:
Debra Quenelle; Gary A Winchester; Jay K Staas; Darrel E Hoskins; Esther W Barrow; William W Barrow
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Drug delivery     Volume:  11     ISSN:  1071-7544     ISO Abbreviation:  Drug Deliv     Publication Date:    2004 Jul-Aug
Date Detail:
Created Date:  2004-09-16     Completed Date:  2005-01-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9417471     Medline TA:  Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  239-46     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Division of Infectious Diseases, University of Alabama at Birmingham, Alabama, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chemistry, Pharmaceutical
Delayed-Action Preparations / administration & dosage,  chemistry,  pharmacokinetics
Female
Macaca fascicularis
Male
Microspheres*
Rifampin / administration & dosage,  chemistry*,  pharmacokinetics*
Grant Support
ID/Acronym/Agency:
AI-36185/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 13292-46-1/Rifampin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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