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Sustained-release adrenomedullin ointment accelerates wound healing of pressure ulcers.
MedLine Citation:
PMID:  21362442     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pressure ulcers are one of the most common complications in elderly, incontinent or paralyzed patients. For the healing of pressure ulcers, the development of granulation tissue and reepithelialization are required. Adrenomedullin (AM), an endogenous vasodilator peptide, is reported to stimulate the proliferation and migration of various cells including endothelial cells, fibroblasts and keratinocytes. Therefore, we hypothesized that AM might accelerate the healing process of pressure ulcers in which these cells were involved. We developed a sustained-release ointment containing human recombinant AM, and applied it in a mouse model of pressure ulcer twice a day for 14days. Human AM was efficiently absorbed in wound area, but its blood concentration was negligible. AM ointment significantly reduced the wound area on day 5 to 7 after injury. In addition, AM ointment accelerated the formation of granulation tissue and angiogenesis as well as lymphangiogenesis after 7days of treatment. Immunological analysis revealed that Ki-67-positive proliferating cells in granulation tissue expressed AM receptors. In summary, sustained-released AM significantly improved wound healing of pressure ulcers through acceleration of granulation and induction of angiogenesis and lymphangiogenesis. Therefore, sustained-release AM ointment may be a novel therapeutic agent for pressure ulcers.
Authors:
Kazuhiko Harada; Kenichi Yamahara; Shunsuke Ohnishi; Kentaro Otani; Hirohisa Kanoh; Hatsue Ishibashi-Ueda; Naoto Minamino; Kenji Kangawa; Noritoshi Nagaya; Tomoaki Ikeda
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-25
Journal Detail:
Title:  Regulatory peptides     Volume:  -     ISSN:  1873-1686     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-3-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010. Published by Elsevier B.V.
Affiliation:
Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan; Department of Perinatology, National Cerebral and Cardiovascular Center, Osaka, Japan; Department of Physiology and Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University, Fukuoka, Japan; Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
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