Document Detail


Sustained reduction of portal pressure by administration of octreotide-LAR in portal hypertensive rats.
MedLine Citation:
PMID:  11164736     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: Recent studies have demonstrated octreotide as being potentially beneficial for the long-term management of cirrhotic portal hypertension. However, its short-term effects, requiring subcutaneous administration at least twice daily, make it inconvenient, practically, for long-term therapy. Hence, the current study was undertaken to evaluate the effects of the new long-acting-release octreotide formulation (octreotide-LAR) on portal pressure in a prehepatic portal hypertensive rat model. Methods: 14 days after portal vein stenosis or sham operation, rats were treated with either octreotide-LAR (0.25 mg/kg body weight, subcutaneously) or vehicle, after the baseline portal pressure measurements were obtained in each group. On days 10, 15, 18, 21, 24, 27 and 30 post-treatment, eight rats from each sub-group (portal vein stenosis plus octreotide-LAR, or vehicle, sham-operated plus octreotide-LAR or vehicle) were subjected to portal vein pressure measurement. Results: portal vein-stenosed rats exhibited a significantly higher portal vein pressure than sham-operated rats (13.82+/-2.18 vs. 5.82+/-1.08 mmHg, P=0.0001). Octreotide-LAR treatment was found to significantly (P=0.001) reduce portal pressure in portal vein stenosed rats from the tenth post-injection day and thereafter to sustain reduction. Conclusion: the long-acting-release octreotide given in a single dose in a prehepatic portal hypertensive rat model diminishes and sustains diminished portal pressure for 20 days after the tenth post-injection day. These findings seem promising for the portal hypertensive patient and further clinical studies are necessary.
Authors:
K Kotzampassi; D Koufogiannis; E Eleftheriadis
Related Documents :
5499036 - Action of kinins on salivary myoepithelial cells.
14607676 - Influence of portal pressure change on intestinal permeability in patients with portal ...
1636786 - Sepsis produces early depression of gut absorptive capacity: restoration with diltiazem...
18185906 - The relation between the spatial distribution of vertebral artery compromise and exposu...
21535726 - Moisture-pressure combination treatments for cyanide reduction in grated cassava.
8324436 - Effectiveness of programme for reducing cardiovascular risk for men in one general prac...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Hepatology research : the official journal of the Japan Society of Hepatology     Volume:  19     ISSN:  -     ISO Abbreviation:  Hepatol. Res.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-Feb-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9711801     Medline TA:  Hepatol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  108-116     Citation Subset:  -    
Affiliation:
Departments of Surgery, University of Thessaloniki, Thessaloniki, Greece
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Characterization of ATP-dependent monoglucuronosyl bilirubin transport across rat canalicular membra...
Next Document:  Regulation of peroxisome proliferator activated receptor alpha-mediated pathways in alcohol fed cyto...