Document Detail


Sustained reduction of hypertension by deep brain stimulation.
MedLine Citation:
PMID:  19664927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deep brain stimulators were implanted in the left periaqueductal gray matter (PAG) and sensory thalamus for right sided neuropathic facial pain refractory to other treatments in a man aged 58 years. PAG stimulation 8 months later acutely reduced systolic blood pressure by 25 mm Hg during revision surgery. One year post procedure, ambulatory blood pressure monitoring demonstrated significant and sustained reduction in blood pressure with PAG stimulation. Mean systolic blood pressure decreased by 12.6mm Hg and diastolic by 11.0mm Hg, alongside reductions in variability of heart rate and pulse pressure. This neurosurgical treatment may prove beneficial for medically refractory hypertension.
Authors:
Erlick A C Pereira; Shouyan Wang; David J Paterson; John F Stein; Tipu Z Aziz; Alexander L Green
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-06
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  17     ISSN:  1532-2653     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  124-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Nuffield Department of Surgery, University of Oxford, Oxford, UK. eacp@eacp.co.uk
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MeSH Terms
Descriptor/Qualifier:
Autonomic Nervous System / physiology,  surgery*
Autonomic Pathways / physiopathology,  surgery
Blood Pressure / physiology*
Chronic Disease / therapy
Deep Brain Stimulation / methods*
Electrodes, Implanted
Facial Pain / complications,  physiopathology,  surgery*
Humans
Hypertension / etiology,  physiopathology,  surgery*
Male
Middle Aged
Periaqueductal Gray / anatomy & histology,  physiology,  surgery*
Thalamus / anatomy & histology,  physiology,  surgery
Treatment Outcome
Grant Support
ID/Acronym/Agency:
//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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