Document Detail

Sustained reduction of hypertension by deep brain stimulation.
MedLine Citation:
PMID:  19664927     Owner:  NLM     Status:  MEDLINE    
Deep brain stimulators were implanted in the left periaqueductal gray matter (PAG) and sensory thalamus for right sided neuropathic facial pain refractory to other treatments in a man aged 58 years. PAG stimulation 8 months later acutely reduced systolic blood pressure by 25 mm Hg during revision surgery. One year post procedure, ambulatory blood pressure monitoring demonstrated significant and sustained reduction in blood pressure with PAG stimulation. Mean systolic blood pressure decreased by 12.6mm Hg and diastolic by 11.0mm Hg, alongside reductions in variability of heart rate and pulse pressure. This neurosurgical treatment may prove beneficial for medically refractory hypertension.
Erlick A C Pereira; Shouyan Wang; David J Paterson; John F Stein; Tipu Z Aziz; Alexander L Green
Related Documents :
23839877 - Interactions of nicardipine to inhalation anesthetics sevoflurane and isoflurane.
20808327 - Role of physical activity and diet in incidence of hypertension: a population-based stu...
9645977 - Carotid endarterectomy does not affect long-term blood pressure: observations from the ...
9635947 - Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hype...
1254417 - Effect of bradykinin on portal pressure and protal caliber in the dog. an experimental ...
2009247 - Review of the major hypertension trials in the elderly.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-06
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  17     ISSN:  1532-2653     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  124-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
Nuffield Department of Surgery, University of Oxford, Oxford, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Autonomic Nervous System / physiology,  surgery*
Autonomic Pathways / physiopathology,  surgery
Blood Pressure / physiology*
Chronic Disease / therapy
Deep Brain Stimulation / methods*
Electrodes, Implanted
Facial Pain / complications,  physiopathology,  surgery*
Hypertension / etiology,  physiopathology,  surgery*
Middle Aged
Periaqueductal Gray / anatomy & histology,  physiology,  surgery*
Thalamus / anatomy & histology,  physiology,  surgery
Treatment Outcome
Grant Support
//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Rooks use stones to raise the water level to reach a floating worm.
Next Document:  The incidence and results of manipulation after primary total knee arthroplasty.