| Sustained reduction of hypertension by deep brain stimulation. | |
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MedLine Citation:
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PMID: 19664927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Deep brain stimulators were implanted in the left periaqueductal gray matter (PAG) and sensory thalamus for right sided neuropathic facial pain refractory to other treatments in a man aged 58 years. PAG stimulation 8 months later acutely reduced systolic blood pressure by 25 mm Hg during revision surgery. One year post procedure, ambulatory blood pressure monitoring demonstrated significant and sustained reduction in blood pressure with PAG stimulation. Mean systolic blood pressure decreased by 12.6mm Hg and diastolic by 11.0mm Hg, alongside reductions in variability of heart rate and pulse pressure. This neurosurgical treatment may prove beneficial for medically refractory hypertension. |
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Authors:
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Erlick A C Pereira; Shouyan Wang; David J Paterson; John F Stein; Tipu Z Aziz; Alexander L Green |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-06 |
Journal Detail:
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Title: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Volume: 17 ISSN: 1532-2653 ISO Abbreviation: J Clin Neurosci Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-06-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433352 Medline TA: J Clin Neurosci Country: Scotland |
Other Details:
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Languages: eng Pagination: 124-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Nuffield Department of Surgery, University of Oxford, Oxford, UK. eacp@eacp.co.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autonomic Nervous System
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physiology,
surgery* Autonomic Pathways / physiopathology, surgery Blood Pressure / physiology* Chronic Disease / therapy Deep Brain Stimulation / methods* Electrodes, Implanted Facial Pain / complications, physiopathology, surgery* Humans Hypertension / etiology, physiopathology, surgery* Male Middle Aged Periaqueductal Gray / anatomy & histology, physiology, surgery* Thalamus / anatomy & histology, physiology, surgery Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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