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Sustained post-exercise vasodilatation and histamine-receptor activation following small muscle-mass exercise in humans.
MedLine Citation:
PMID:  22848080     Owner:  NLM     Status:  Publisher    
A sustained post-exercise vasodilatation which is histamine-receptor mediated has been observed following single bouts of whole-body exercise, but the mechanisms that regulate activation of histamine receptors following exercise are undefined. Exploration of vasodilatation after small muscle-mass dynamic or resistance exercise could provide novel insight into the pathways responsible for histamine-receptor activation. We hypothesized that there would be a vasodilatation of the previously exercised limb following small-muscle mass dynamic and resistance exercise which would be mediated by histamine receptors. We studied men and women before and after single-leg dynamic (n=9) or resistance knee-extension exercise (n=12) on control and blockade days (combined oral H1- and H2-receptor antagonism with fexofenadine and ranitidine). We measured arterial blood pressure (automated brachial oscillometry) and femoral artery blood flow (Doppler ultrasound). Dynamic exercise elevated leg vascular conductance in the active leg by 27.2±8.4% at 60 min post-exercise (P < 0.05 vs. pre-exercise), but did not alter conductance in the rested leg (Δ 4.6±3.5%; P = 0.8 vs. pre-exercise). The rise in conductance was abolished on the blockade day (Δ 3.7±5.1%; P = 0.8 vs. pre-exercise, P = 0.2 vs. control). Resistance exercise did not produce a sustained vasodilatation (Δ -4.3±4.7% at 60 min post-exercise; P = 0.7 vs. pre-exercise). These data indicate that histamine receptors are activated following dynamic, but not resistance exercise. Further, these data suggest that local factors associated with aerobic exercise, and not systemic factors or factors associated with high muscle force, are responsible for activation of histamine receptors in the previously exercised muscle.
Zachary Barrett-O'Keefe; Rachelle E Kaplon; John R Halliwill
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-30
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Oregon.
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