| Sustained local delivery of heparin to the rabbit arterial wall with an electroporation catheter. | |
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MedLine Citation:
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PMID: 9829901 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current methods of local drug delivery frequently fail to achieve a prolonged therapeutically effective tissue drug level without producing vascular trauma. A novel double-balloon catheter system, incorporating electroporation technology, has been designed and tested to deliver heparin into rabbit carotid arteries in an overstretch balloon injury model in vivo. Following arterial injury, fluoresceinated heparin was delivered into the volume between the two inflated balloons, and the artery was subjected to an electrical pulse. Catheter deployment and endovascular electrical pulsing were well-tolerated in all animals (N = 21) without adverse hemodynamic and histological changes. Periodic arterial blood samples revealed no abnormalities in the clotting profile or any gross morphological changes in the blood cells up to 8 hr after treatment. Much stronger heparin fluorescence was detected throughout the vessel layers for at least 12 hr in the pulsed samples compared to the control. Histochemical staining of the tissue showed intracellular localization of heparin. Endovascular electroporation may provide better retention and higher therapeutic efficacy than can be achieved by conventional systemic delivery of heparin at clinically safe concentrations. |
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Authors:
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N B Dev; T J Preminger; G A Hofmann; S B Dev |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Catheterization and cardiovascular diagnosis Volume: 45 ISSN: 0098-6569 ISO Abbreviation: Cathet Cardiovasc Diagn Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-01-20 Completed Date: 1999-01-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7508512 Medline TA: Cathet Cardiovasc Diagn Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 337-45 Citation Subset: IM |
Affiliation:
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Division of Pediatric Cardiology, Case Western Reserve University, Cleveland, Ohio, USA. nbdev@genetronics.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticoagulants / administration & dosage*, pharmacokinetics Blood Pressure Carotid Artery, Common / drug effects, metabolism, pathology Carotid Stenosis / drug therapy, metabolism, pathology Catheterization, Peripheral / instrumentation* Disease Models, Animal Drug Delivery Systems / instrumentation* Electroporation* Female Heparin / administration & dosage*, pharmacokinetics Injections, Intra-Arterial Male Rabbits Safety Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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