| Sustained intracerebroventricular infusion of brain fuels reduces body weight and food intake in rats. | |
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MedLine Citation:
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PMID: 7193909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Long-term infusion of glucose, beta-hydroxybutyrate, and glycerol into the third ventricle of the rat brain caused a stabilization of body weight at a lower than normal level. Among the glucose- and glycerol-treated animals this weight loss was caused in part by temporary hypophagia. Among the animals treated with beta-hydroxybutyrate the weight loss was unaccompanied by a reduction in food intake. The results are consistent with the view that the systems controlling food intake and body weight are sensitive to the availability of brain fuels. They are not consistent however, with the view that these control systems monitor calories independently of their source. |
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Authors:
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J D Davis; D Wirtshafter; K E Asin; D Brief |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 212 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1981 Apr |
Date Detail:
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Created Date: 1981-05-21 Completed Date: 1981-05-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 81-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxybutyric Acid Animals Appetite Regulation* / drug effects Body Weight* / drug effects Brain / drug effects, physiology* Circadian Rhythm Drinking / drug effects Eating* / drug effects Glucose / pharmacology* Glycerol / pharmacology* Hydroxybutyrates / administration & dosage, pharmacology* Hypothalamus / drug effects Injections, Intraventricular Male Rats |
| Grant Support | |
ID/Acronym/Agency:
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AM 26030/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hydroxybutyrates; 300-85-6/3-Hydroxybutyric Acid; 50-99-7/Glucose; 56-81-5/Glycerol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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