Document Detail

Sustained increases in plasma epinephrine concentration do not modulate renin release.
MedLine Citation:
PMID:  2665519     Owner:  NLM     Status:  MEDLINE    
We examined the relationship between plasma renin activity (PRA) and renal arterial pressure (RAP) during 1) control conditions, 2) acute, and 3) chronic intravenous epinephrine (EPI) infusion (125 In eight conscious uninephrectomized dogs maintained on a normal sodium intake, the renin stimulus-response curve (RSRC) was determined by a stepwise reduction in RAP with an inflatable occluder around the renal artery controlled by a servo unit. The RSRC could be approximated by two lines intersecting at a threshold pressure (approximately 20 mmHg below control RAP). In the high-pressure range, PRA was relatively insensitive to changes in RAP, whereas, below threshold pressure, changes in RAP had large effects on PRA. During acute EPI infusion there was approximately a 40% increase in heart rate (control = 57 +/- 3 beats/min) and hematocrit (control = 30 +/- 1%) in association with a rise in plasma EPI concentration from 73 +/- 16 to 1,413 +/- 100 pg/ml; mean arterial pressure (MAP) was unchanged (94 +/- 3 mmHg). Moreover, EPI acutely increased basal PRA from 0.3 +/- 0.1 to 0.8 +/- 0.3 ng angiotensin and shifted the RSRC to the right (increasing threshold pressure 7 mmHg) without altering the slope of the RSRC curve either above or below threshold pressure. In contrast, although plasma EPI concentration and hematocrit remained elevated during chronic EPI infusion, heart rate and basal PRA returned to preinfusion values. In addition, there were no significant long-term changes in MAP or in any of the parameters of the RSRC.(ABSTRACT TRUNCATED AT 250 WORDS)
H M Yang; T E Lohmeier; S D Kivlighn; R G Carroll; M J Smith
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  257     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-11     Completed Date:  1989-08-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E57-64     Citation Subset:  IM    
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505.
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MeSH Terms
Blood Pressure* / drug effects
Epinephrine / administration & dosage,  blood*,  pharmacology
Heart Rate / drug effects
Natriuresis / drug effects
Norepinephrine / blood
Potassium / blood,  urine
Renal Artery / physiology
Renin / blood,  secretion*
Grant Support
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7440-09-7/Potassium; EC

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