Document Detail

Sustained improvement with iloprost in a COPD patient with severe pulmonary hypertension.
MedLine Citation:
PMID:  19201716     Owner:  NLM     Status:  MEDLINE    
Pulmonary hypertension is an important complication of COPD. A small subset of patients with COPD have severe pulmonary hypertension (PH) that is out of proportion to the mild increase in pulmonary arterial pressure observed commonly. Severe PH associated with COPD is associated with increased morbidity and mortality. Treatment options in this group of patients are limited with no conclusive evidence of benefit when drugs approved for treatment of pulmonary arterial hypertension are used. We describe a patient with severe PH associated with COPD who improved clinically and hemodynamically when treated with inhaled iloprost. The improvement was sustained for 2 years. Severe PH in patients with COPD needs to be recognized and novel treatment approaches considered.
Matthew J Hegewald; C Gregory Elliott
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  135     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  536-7     Citation Subset:  AIM; IM    
Division of Pulmonary and Critical Care Medicine Intermountain Medical Center, University of Utah School of Medicine, Salt Lake City, UT 84157-7000, USA.
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MeSH Terms
Administration, Inhalation
Blood Gas Analysis
Dose-Response Relationship, Drug
Drug Administration Schedule
Echocardiography, Transesophageal
Follow-Up Studies
Hypertension, Pulmonary / drug therapy*,  etiology,  ultrasonography
Iloprost / administration & dosage*
Maximum Tolerated Dose
Pulmonary Disease, Chronic Obstructive / complications*,  diagnosis
Respiratory Function Tests
Risk Assessment
Severity of Illness Index
Treatment Outcome
Vasodilator Agents / administration & dosage*
Reg. No./Substance:
0/Vasodilator Agents; 78919-13-8/Iloprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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