Document Detail

Sustained improvement in gas exchange after negative pressure ventilation for 8 hours per day on 2 successive days in chronic airflow limitation.
MedLine Citation:
PMID:  1859065     Owner:  NLM     Status:  MEDLINE    
Negative pressure ventilation (NPV) was applied for 6 to 8 h/day for 2 consecutive days in 13 patients with severe airflow limitation and chronic respiratory failure. After cessation of NPV, the mean arterial blood gases were improved in 10 patients, and this improvement was sustained for the nex 2 days in eight patients, for 3 days in seven patients, and was still present in four patients on the fourth day. Respiratory muscle strength improved in all patients, but there was no relationship between the increase in strength and sustained improvement in gas exchange. Ventilation and respiratory pattern were unchanged in all patients, but the mean VD/VT fell and VA rose while the VO2 and VCO2 fell. The ventilatory responses to hypoxia and hypercapnia increased in patients who demonstrated sustained improvement in blood gases. The mechanism underlying the sustained improvement in gas exchange following NPV is not clear but is likely multifactorial.
E Fernandez; P Weiner; E Meltzer; M M Lutz; D B Badish; R M Cherniack
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  144     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-08-29     Completed Date:  1991-08-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  390-4     Citation Subset:  AIM; IM    
Department of Medicine, University of Colorado Health Sciences Center, Denver.
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MeSH Terms
Lung Diseases, Obstructive / physiopathology,  therapy*
Middle Aged
Pulmonary Gas Exchange / physiology*
Respiration, Artificial / methods
Respiratory Insufficiency / therapy
Respiratory Muscles / physiology
Time Factors
Ventilators, Negative-Pressure*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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