Document Detail

Sustained haemodynamic action of nitroglycerin ointment.
MedLine Citation:
PMID:  823949     Owner:  NLM     Status:  MEDLINE    
Intravenous vasodilators have been shown to improve the haemodynamic status of patients in congestive heart failure. However, neither intravenous nor sublingual preparations are suitable for chronic administration or use in ambulatory patients. In this study, nitroglycerin ointment bas administered to 11 patients in congestive heart failure. Mean pulmonary wedge and arterial pressures, as well as systemic blood pressures and heart rate were then monitored for 2 to 5 hours and compared with baseline values. Pulmonary wedge and arterial pressures, as well as systemic systolic arterial pressure, decreased significantly at 15 minutes after application and remained depressed for up to 5 hours. Systemic diastolic pressures fell significantly at 30 minutes and also remained significantly reduced for up to 5 hours. Thus, nitroglycerin ointment may be suitable for chronic vasodilator therapy of congestive heart failure.
S G Meister; T R Engel; N Guiha; C M Furr; G S Feitosa; K Hart; W S Frankl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  38     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1031-6     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Depression, Chemical
Heart Failure / drug therapy*
Heart Rate / drug effects
Middle Aged
Nitroglycerin / administration & dosage,  therapeutic use*
Pulmonary Artery
Time Factors
Reg. No./Substance:
0/Ointments; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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