Document Detail

Sustained elevation of extracellular ATP in aqueous humor from humans with primary chronic angle-closure glaucoma.
MedLine Citation:
PMID:  21745471     Owner:  NLM     Status:  MEDLINE    
While the death of retinal ganglion cells in glaucoma is frequently associated with an elevation of intraocular pressure (IOP), the mechanisms connecting the two processes remain unclear. Extracellular ATP is released throughout the body in response to mechanical deformations. We have previously shown that patients with an acute rise in IOP have an elevated concentration of ATP in the anterior chamber. In the present study we ask whether ATP levels remain increased in patients with chronic elevations of IOP. The concentration of ATP in samples of aqueous humor obtained from patients with primary chronic angle-closure glaucoma (PCACG) was compared with that from control cataract patients whose IOP was normal. The mean ATP concentration in aqueous humor was 14-fold higher for PCACG samples than for control. ATP levels were correlated with IOP and the cup-to-disk ratio (C/D ratio). Brief treatment of Timolol, Alphagan, Pilocarpine and/or Azopt did not affect the rise in ATP concentration. In conclusion, sustained elevations in extracellular ATP levels accompany the chronic elevation of IOP in chronic glaucoma. As numerous ocular tissues express purinergic receptors, an increased extracellular ATP may have diverse physiological and pathophysiological effects.
Ang Li; Xiulan Zhang; Danying Zheng; Jian Ge; Alan M Laties; Claire H Mitchell
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-07-02
Journal Detail:
Title:  Experimental eye research     Volume:  93     ISSN:  1096-0007     ISO Abbreviation:  Exp. Eye Res.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-11-01     Completed Date:  2012-01-16     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0370707     Medline TA:  Exp Eye Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  528-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, People's Republic of China.
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MeSH Terms
Adenosine Triphosphate / metabolism*
Antihypertensive Agents / therapeutic use
Aqueous Humor / metabolism*
Chronic Disease
Glaucoma, Angle-Closure / drug therapy,  metabolism*
Intraocular Pressure / drug effects
Luminescent Measurements
Middle Aged
Grant Support
EY 015537/EY/NEI NIH HHS; R01 EY013434/EY/NEI NIH HHS; R01 EY015537/EY/NEI NIH HHS
Reg. No./Substance:
0/Antihypertensive Agents; 56-65-5/Adenosine Triphosphate

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