| Sustained drug delivery systems II: Factors affecting release rates from poly(epsilon-caprolactone) and related biodegradable polyesters. | |
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MedLine Citation:
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PMID: 529046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The release rates of several steroids from films and capsules of homopolymers and copolymer of epsilon-caprolactone, DL-lactic acid, and glycolic acid were measured in vitro and in vivo for up to 200 days. Relatively constant release rates from capsules (reservoir devices) were observed only under certain conditions. Factors that influence the drug release kinetics were evaluated. Release from poly(epsilon-caprolactone) and poly(epsilon-caprolactone-co-DL-lactic acid) was diffusion controlled. Release from poly(DL-lactic acid-co-glycolic acid) was associated with polymer degradation. Release from poly(DL-lactic acid) was very slow when diffusion controlled. |
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Authors:
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C G Pitt; M M Gratzl; A R Jeffcoat; R Zweidinger; A Schindler |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 68 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1979 Dec |
Date Detail:
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Created Date: 1980-04-23 Completed Date: 1980-04-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1534-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Crystallization Delayed-Action Preparations Diffusion Lactones Membranes, Artificial Polyesters* Polymers* Steroids Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 0/Lactones; 0/Membranes, Artificial; 0/Polyesters; 0/Polymers; 0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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