| Sustained delivery of lidocaine into the cochlea using poly lactic/glycolic acid microparticles. | |
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MedLine Citation:
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PMID: 19950377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES/HYPOTHESIS: Lidocaine is a local anesthetic that is known to suppress tinnitus via systemic or local application; however, this effect has only limited duration. The current study aimed to establish a method for the sustained delivery of lidocaine into the cochlea using poly lactic/glycolic acid (PLGA) microparticles. STUDY DESIGN: Experimental study. METHODS: Lidocaine-loaded PLGA microparticles were produced and their in vitro-release profiles were examined. The lidocaine concentrations in the perilymph were measured at different time points following the application of the lidocaine-loaded PLGA microparticles to the round-window membranes of guinea pigs. The possible adverse effects of the local application of lidocaine-loaded PLGA microparticles were also examined. RESULTS: The in vitro analyses revealed that the microparticles were capable of the sustained delivery of lidocaine. The in vivo experiments demonstrated the sustained delivery of lidocaine into the cochlear fluid, and the maintenance of high lidocaine concentrations in the perilymph for up to 3 days after application. Nystagmus and inflammation in the middle ear mucosa were not detected after the local application of lidocaine-loaded PLGA microparticles, although temporary hearing loss was observed. CONCLUSIONS: Lidocaine-loaded PLGA microparticles were shown to be capable of the sustained delivery of lidocaine into the cochlea, suggesting that they could be used for the attenuation of peripheral tinnitus. |
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Authors:
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Rie T Horie; Tatsunori Sakamoto; Takayuki Nakagawa; Yasuhiko Tabata; Noboru Okamura; Naoki Tomiyama; Mitsuhiro Tachibana; Juichi Ito |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Laryngoscope Volume: 120 ISSN: 1531-4995 ISO Abbreviation: Laryngoscope Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-26 Completed Date: 2010-02-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: United States |
Other Details:
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Languages: eng Pagination: 377-83 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Local
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administration & dosage*,
adverse effects,
pharmacokinetics Animals Biocompatible Materials Cochlea* Drug Carriers* / adverse effects Drug Delivery Systems* Ear, Middle / drug effects, pathology Evoked Potentials, Auditory, Brain Stem / drug effects Female Guinea Pigs Lactic Acid* / adverse effects Lidocaine / administration & dosage*, adverse effects, pharmacokinetics Microspheres Polyglycolic Acid* / adverse effects Surface Properties Vestibular Function Tests |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Biocompatible Materials; 0/Drug Carriers; 0/polylactic acid-polyglycolic acid copolymer; 137-58-6/Lidocaine; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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