| Sustained decrease and remarkable increase of red blood cell velocity in intraparenchymal capillaries associated with potassium-induced cortical spreading depression. | |
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MedLine Citation:
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PMID: 21992739 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives: To examine changes of red blood cell (RBC) velocity in intraparenchymal capillaries of rat cerebral cortex in response to KCl-induced cortical spreading depression (CSD). Methods: In isoflurane-anesthetized rats, the velocity of fluorescently labeled RBCs flowing in capillaries in layer I was measured with a high-speed camera laser-scanning confocal fluorescence microscope, with simultaneous monitoring of DC potential, the electroencephalogram (EEG), partial pressure of oxygen (PO(2) ) and cerebral blood flow (CBF). Results: After KCl application, a transient deflection of DC potential (i.e., CSD) repeatedly appeared concomitantly with depression of EEG, and was propagated in the distal direction. PO(2) transiently decreased and CBF was slowly elevated. The frequency distribution of RBC velocity was shifted downwards during CSD and was still low after the passage of CSD. When we observed RBC velocity in 38 individual capillaries, 10 capillaries exhibited slowed-down RBC during CSD and RBC velocity remained low in 2 even after the passage of CSD. On the other hand, RBCs with moderately (< 3 mm/s) or remarkably (> 3 mm/s) increased velocities were seen in 10 and 5 capillaries, respectively. Conclusion: CSD-induced excitation of neurons may sustainably decrease or greatly increase RBC velocity in capillaries. |
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Authors:
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Miyuki Unekawa; Minoru Tomita; Yutaka Tomita; Haruki Toriumi; Norihiro Suzuki |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-12 |
Journal Detail:
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Title: Microcirculation (New York, N.Y. : 1994) Volume: - ISSN: 1549-8719 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 John Wiley & Sons Ltd. |
Affiliation:
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Department of Neurology, School of Medicine, Keio University. 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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