Document Detail

Sustained coronary constriction and its antagonism by calcium-blocking agents in monkeys and baboons.
MedLine Citation:
PMID:  6403259     Owner:  NLM     Status:  MEDLINE    
Experiments were performed on five Japanese monkeys and one anubis baboon anesthetized initially with ketamine hydrochloride and subsequently with sodium pentobarbital, and maintained on artificial respiration. The left anterior descending coronary artery (LAD) was cannulated and its vascular bed was perfused with arterial blood. Perfusion pressure was kept constant at a value slightly higher than the mean systemic arterial pressure. Blood flow through the LAD was measured by an electromagnetic flow meter. All drugs were administered into the LAD. Single injections of acetylcholine produced a biphasic change in blood flow; an initial decrease (vasoconstriction) followed by an increase (vasodilation). Infusion of acetylcholine produced a sustained decrease in blood flow in all the animals used except one Japanese monkey in which oscillatory changes in blood flow were induced. With infusions of acetylcholine, however, left ventricular pressure (LVP), and maximum rate of rise of LVP (LV dP/dt max), heart rate, and systemic arterial pressure remained unchanged. Single injections of diltiazem and nifedipine, calcium-blocking agents, and nitroglycerin produced a dose-related increase in blood flow. Diltiazem and nifedipine exerted no effects on other cardiohemodynamic variables, whereas nitroglycerin produced a decrease in systemic arterial pressure and an increase in heart rate. When blood flow through the LAD was reduced to nearly half of the basal value by infusion of acetylcholine, diltiazem and nifedipine produced an increase in blood flow as much as in control, whereas nitroglycerin produced less of an increase than in control.
N Taira; K Satoh; M Maruyama; S Yamashita
Related Documents :
8186399 - Characteristics of coronary artery inflow and its significance in coronary pathophysiol...
3488139 - Von willebrand's disease prevents occlusive thrombosis in stenosed and injured porcine ...
11675649 - Effects of flow and energy metabolism on injury and rb(+) uptake in pig hearts: an (87)...
12805399 - High serum leptin is associated with attenuated coronary vasoreactivity.
16760869 - How to discriminate between hibernating and stunned myocardium.
12881769 - Coronary blood flow in healthy neonates: effects of left ventricular function and mass.
21629259 - A computational simulation of the effect of hemodilution on oxygen transport in middle ...
2010109 - Maternal blood volume in placenta of the rhesus monkey measured in vivo by positron emi...
4006979 - Can technetium-labelled millimicrospheres be used to measure kupffer-cell function? an ...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation research     Volume:  52     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I40-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acetylcholine / pharmacology
Calcium Channel Blockers / pharmacology*
Coronary Circulation / drug effects
Coronary Vessels / drug effects*
Diltiazem / pharmacology
Nifedipine / pharmacology
Nitroglycerin / pharmacology
Vasoconstriction / drug effects*
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 42399-41-7/Diltiazem; 51-84-3/Acetylcholine; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of effects of nifedipine and nitroglycerin on large and small coronary arteries and cardi...
Next Document:  "Sandwich" enzyme immunoassay for serum ferritin with polypropylene test tubes as the solid phase.