Document Detail


Sustained cognitive benefit 5 years after carotid endarterectomy.
MedLine Citation:
PMID:  20299177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study investigated the long-term effect of carotid endarterectomy (CEA) on cognitive brain function by means of P300 evoked potentials.
METHODS: Twenty-five consecutive patients (36% women) with a median age of 68 years underwent CEA with a median degree of stenosis of 90%. Cognitive brain function was objectively measured by means of P300 auditory evoked potentials (peak latencies in milliseconds [ms]) before CEA, at discharge, and at 1 and 5 years. Values were compared with 25 age- and sex-matched healthy individuals.
RESULTS: Cognitive P300 evoked potentials were prolonged (ie, impaired) in patients before CEA compared with controls (vertex [Cz], 384 +/- 52 vs 357 +/- 16 ms, P = .020]. At 1 year, P300 evoked potentials were significantly shortened (ie, improved) in patients after CEA compared with baseline values [Cz, 371 +/- 38 vs 384 +/- 52 ms, P = .010]. Furthermore, no difference between patients after CEA and controls was observed [Cz, 371 +/- 38 vs 360 +/- 14 ms, P = .21]. This effect was sustained at 5 years, and P300 evoked potentials continued to be significantly shortened (ie, improved) in patients after CEA compared with baseline values [Cz, 367 +/- 39 vs 384 +/- 52 ms, P = .040]. Continuing, no difference between patients after CEA and controls could be observed [Cz, 367 +/- 39 vs 362 +/- 17 ms, P = .58]. These results could be confirmed in repeated measures analysis of variance for Cz (P = .025) and frontal (Fz) results (P = .018).
CONCLUSIONS: CEA improves previously impaired cognitive brain function as shown by P300 measurements similar to normal cognitive brain function of age- and sex-matched healthy individuals. This beneficial effect is sustained up to 5 years after treatment.
Authors:
Martin Czerny; Philipp Schuch; Gottfried Sodeck; Csilla Bálassy; Thomas Hoelzenbein; Andrzej Juraszek; Tomasz Dziodzio; Michael Grimm
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2010-03-29
Journal Detail:
Title:  Journal of vascular surgery     Volume:  51     ISSN:  1097-6809     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-27     Completed Date:  2010-05-12     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1139-44     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.
Affiliation:
Department of Cardiovascular Surgery, University Hospital Berne, Berne, Switzerland. martin.czerny@meduniwien.ac
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Carotid Stenosis / surgery*,  ultrasonography
Case-Control Studies
Cognition / physiology*
Cognition Disorders / diagnosis,  prevention & control*
Endarterectomy, Carotid / adverse effects,  methods*
Event-Related Potentials, P300*
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neuropsychological Tests
Probability
Reference Values
Risk Assessment
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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