| Sustained bone mineral density changes after burn injury. | |
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MedLine Citation:
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PMID: 14559443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Body-composition changes have been observed after burn injury. In particular, several studies have shown that bone mineral density (BMD) in burn patients is decreased when compared to the normal population. Little is known about the frequency, severity, or duration of these changes. The purpose of this study was to describe body-composition changes over time after burn injury. MATERIALS AND METHODS: Twenty-nine burn patients participated in this study. Portable dual-energy X-ray absorptiometry (pDEXA) measuring forearm BMD, fat, and lean mass was obtained as soon as possible after admission and repeated bi-weekly until discharge and, when possible, for 2 years post-injury. The scan showing the greatest change in BMD, fat, or lean mass was compared to the baseline scan for each individual. RESULTS: Although lean and fat mass did not change significantly after injury, BMD decreased significantly. The greatest change in BMD did not occur during the acute burn hospitalization, but rather 131 days after burn injury. Changes in post-burn BMD inversely correlated with % total body surface area (TBSA) and % 3rd-degree TBSA. The magnitude of change was similar between adults and children. CONCLUSIONS: These results confirm earlier studies, suggesting that BMD can be negatively altered post-injury, with the greatest changes occurring after patients are discharged from the hospital. Although the clinical significance of these changes is not known, this study supports the need for long-term musculoskeletal assessments in burn patients and for further research to elucidate the mechanisms of burn-induced body-composition changes. |
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Authors:
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Linda S Edelman; Teresa McNaught; Gary M Chan; Stephen E Morris |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of surgical research Volume: 114 ISSN: 0022-4804 ISO Abbreviation: J. Surg. Res. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-10-15 Completed Date: 2003-11-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: United States |
Other Details:
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Languages: eng Pagination: 172-8 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA. linda.edelman@hsc.utah.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon
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methods Adipose Tissue / anatomy & histology Adult Age Factors Body Composition / physiology Bone Density / physiology* Burns / physiopathology* Follow-Up Studies Humans Middle Aged Radius Reference Values Time Factors Ulna |
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