Document Detail


Sustained acceleration in carotid atherosclerotic plaque progression with intraplaque hemorrhage: a long-term time course study.
MedLine Citation:
PMID:  22897993     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study sought to determine the immediate and long-term effects of intraplaque hemorrhage (IPH) on plaque progression in the carotid artery.
BACKGROUND: Previous studies have associated IPH in the carotid artery with more rapid plaque progression. However, the time course and long-term effect remain unknown. Carotid magnetic resonance imaging is a noninvasive imaging technique that has been validated with histology for the accurate in vivo detection of IPH and measurement of plaque burden.
METHODS: Asymptomatic subjects with 50% to 79% carotid stenosis underwent carotid magnetic resonance imaging at baseline and then serially every 18 months for a total of 54 months. Subjects with IPH present in at least 1 carotid artery at 54 months were selected. Subsequently, presence/absence of IPH and wall volume were determined independently in all time points for both sides. A piece-wise progression curve was fit by using a linear mixed model to compare progression rates described as annualized changes in wall volume between periods defined by their relationship to IPH development.
RESULTS: From 14 subjects who exhibited IPH at 54 months, 12 arteries were found to have developed IPH during the study period. The progression rates were -20.5 ± 13.1, 20.5 ± 13.6, and 16.5 ± 10.8 mm(3)/year before, during, and after IPH development, respectively. The progression rate during IPH development tended to be higher than the period before (p = 0.080) but comparable to the period after (p = 0.845). The progression rate in the combined period during/after IPH development was 18.3 ± 6.5 mm(3)/year, which indicated significant progression (p = 0.008 compared with a slope of 0) and was higher than the period before IPH development (p = 0.018). No coincident ischemic events were noted for new IPH.
CONCLUSIONS: The development of IPH posed an immediate and long-term promoting effect on plaque progression. IPH seems to alter the biology and natural history of carotid atherosclerosis. Early identification of patients with IPH may prove invaluable in optimizing management to minimize future sequelae.
Authors:
Jie Sun; Hunter R Underhill; Daniel S Hippe; Yunjing Xue; Chun Yuan; Thomas S Hatsukami
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  JACC. Cardiovascular imaging     Volume:  5     ISSN:  1876-7591     ISO Abbreviation:  JACC Cardiovasc Imaging     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-17     Completed Date:  2013-02-12     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  101467978     Medline TA:  JACC Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  798-804     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Radiology, University of Washington, Seattle, WA, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Carotid Artery, Internal / pathology
Carotid Stenosis / complications,  drug therapy,  pathology*
Disease Progression
Female
Hemorrhage / pathology*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Image Processing, Computer-Assisted
Magnetic Resonance Spectroscopy
Male
Middle Aged
Retrospective Studies
Grant Support
ID/Acronym/Agency:
P01 HL072262/HL/NHLBI NIH HHS; P01 HL072262/HL/NHLBI NIH HHS; R01 HL061851/HL/NHLBI NIH HHS; R01 HL061851/HL/NHLBI NIH HHS; R01 HL073401/HL/NHLBI NIH HHS; R01 HL073401/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors
Comments/Corrections
Comment In:
JACC Cardiovasc Imaging. 2012 Nov;5(11):1185-6   [PMID:  23153923 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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