Document Detail


Sustainable release of carmustine from biodegradable poly[(d,l)-lactide-co-glycolide] nanofibrous membranes in the cerebral cavity: in vitro and in vivo studies.
MedLine Citation:
PMID:  23289446     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. The only interstitial chemotherapy pharmaceutical approved to date for GBM treatment is the Gliadel® wafer. Despite the safety and efficacy of this approach that have been demonstrated in patients undergoing resection of both newly diagnosed and recurrent malignant gliomas, the wafer provides an effective release of the anticancer 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) for only 5 days. Methods: In this study, the authors developed biodegradable poly[(d,l)-lactide-co-glycolide] nanofibrous membranes via electrospinning that provided a sustained release of BCNU. An elution method and a HPLC assay were employed to characterize the in vitro and in vivo release behaviors of pharmaceuticals from the electrospun membranes. Results: The experimental results show that the biodegradable, nanofibrous membranes released high concentrations of BCNU for more than 6 weeks in the cerebral cavity of rats. Furthermore, the membranes can better conform to the geometry of the brain tissue and can cover more completely the tissue after the removal of tumors, achieving better drug transport without interfering with the normal function of the brain. Histological examination showed no obvious inflammation reactions of the brain tissues. Conclusion: Adopting the electrospinning technique will help in manufacturing biodegradable, nanofibrous membranes for the long-term deliveries of various anticancer drugs in the cerebral cavity, which will further enhance the therapeutic efficacy of GBM treatment.
Authors:
Yuan-Yun Tseng; Jun-Yi Liao; Wei-An Chen; Yu-Chun Kao; Shih-Jung Liu
Related Documents :
2579396 - Acidic ph requirement for insertion of colicin e1 into artificial membrane vesicles: re...
15198596 - Partitioning of dual-lipidated peptides into membrane microdomains: lipid sorting vs pe...
16851756 - Temperature weighted histogram analysis method, replica exchange, and transition paths.
22629966 - The effects of graphene doping on the in-field jc of mgb2 wires.
9264096 - Behavioral and autonomic thermoregulation in the rat following propylthiouracil-induced...
15563756 - Determination of diffusion coefficients of peptides and prediction of permeability thro...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-7
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  -     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Taipei Medical University, Shuang Ho Hospital, Department of Neurosurgery , Taipei , Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeut...
Next Document:  A new central-peripheral corneal curvature method for intraocular lens power calculation after excim...