Document Detail


Suspended microtubules demonstrate high sensitivity and low experimental variability in kinesin bead assay.
MedLine Citation:
PMID:  23376984     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Microtubule (MT) based intraneuronal transport deficiency is directly linked to neurodegeneration. Hence, the development of a reliable and sensitive in vitro approach permitting efficient analysis of MT-based transport is essential for our understanding of the underlying molecular mechanisms that may lead to novel therapeutic approaches for treating neurodegenerative diseases. Here, based on previously developed reconstructed MT-kinesin assay, we propose its "suspended" modification that shows higher sensitivity and lower experimental variability.
Authors:
Mehmet C Tarhan; Yslam Orazov; Ryuji Yokokawa; Stanislav L Karsten; Hiroyuki Fujita
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-4
Journal Detail:
Title:  The Analyst     Volume:  -     ISSN:  1364-5528     ISO Abbreviation:  Analyst     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372652     Medline TA:  Analyst     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Center for International Research on Micronano Mechatronic, Institute of Industrial Science, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8505, Japan. mctarhan@iis.u-tokyo.ac.jp orazov@iis.u-tokyo.ac.jp fujita@iis.u-tokyo.ac.jp.
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