Document Detail

Suspended animation, diapause and quiescence: arresting the cell cycle in C. elegans.
MedLine Citation:
PMID:  22510566     Owner:  NLM     Status:  MEDLINE    
Developing organisms require nutrients to support cell division vital for growth and development. An adaptation to stress, used by many organisms, is to reversibly enter an arrested state by reducing energy-requiring processes, such as development and cell division. This "wait it out" approach to survive stress until the environment is conductive for growth and development is used by many metazoans. Much is known about the molecular regulation of cell division, metazoan development and responses to environmental stress. However, how these biological processes intersect is less understood. Here, we review studies conducted in Caenorhabditis elegans that investigate how stresses such as oxygen deprivation (hypoxia and anoxia), exogenous chemicals or starvation affect cellular processes in the embryo, larvae or adult germline. Using C. elegans to identify how stress signals biological arrest can help in our understanding of evolutionary pressures as well as human health-related issues.
Pamela A Padilla; Mary L Ladage
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-05-01
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  11     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-17     Completed Date:  2012-09-17     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1672-9     Citation Subset:  IM    
Department of Biological Sciences, University of North Texas, Denton, TX, USA.
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MeSH Terms
Benomyl / pharmacology
Blastomeres / cytology,  metabolism
Caenorhabditis elegans / cytology*,  drug effects,  metabolism
Cell Cycle Checkpoints*
Cell Differentiation
Cell Division
Embryo, Nonmammalian / cytology,  drug effects,  metabolism
Embryonic Development
Germ Cells / metabolism
Larva / cytology,  drug effects,  metabolism
Oocytes / cytology,  metabolism
Oxygen / metabolism*
Stress, Physiological
Reg. No./Substance:
17804-35-2/Benomyl; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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