| Suspended animation, diapause and quiescence: arresting the cell cycle in C. elegans. | |
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MedLine Citation:
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PMID: 22510566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Developing organisms require nutrients to support cell division vital for growth and development. An adaptation to stress, used by many organisms, is to reversibly enter an arrested state by reducing energy-requiring processes, such as development and cell division. This "wait it out" approach to survive stress until the environment is conductive for growth and development is used by many metazoans. Much is known about the molecular regulation of cell division, metazoan development and responses to environmental stress. However, how these biological processes intersect is less understood. Here, we review studies conducted in Caenorhabditis elegans that investigate how stresses such as oxygen deprivation (hypoxia and anoxia), exogenous chemicals or starvation affect cellular processes in the embryo, larvae or adult germline. Using C. elegans to identify how stress signals biological arrest can help in our understanding of evolutionary pressures as well as human health-related issues. |
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Authors:
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Pamela A Padilla; Mary L Ladage |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2012-05-01 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 11 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-17 Completed Date: 2012-09-17 Revised Date: 2013-05-02 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 1672-9 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, University of North Texas, Denton, TX, USA. ppadilla@unt.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benomyl / pharmacology Blastomeres / cytology, metabolism Caenorhabditis elegans / cytology*, drug effects, metabolism Cell Cycle Checkpoints* Cell Differentiation Cell Division Embryo, Nonmammalian / cytology, drug effects, metabolism Embryonic Development Germ Cells / metabolism Larva / cytology, drug effects, metabolism Oocytes / cytology, metabolism Oxygen / metabolism* Stress, Physiological |
| Chemical | |
Reg. No./Substance:
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17804-35-2/Benomyl; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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