Document Detail

Suspected allopurinol-induced aseptic meningitis.
MedLine Citation:
PMID:  11718488     Owner:  NLM     Status:  MEDLINE    
Drug-induced aseptic meningitis is a syndrome with symptoms similar to those of infectious meningitis. A 60-year-old man with a history of recurrent renal stones was admitted to the hospital with fever, chills, and mental status changes after taking levofloxacin, allopurinol, and acetazolamide. No infectious source was identified. Once home, he resumed allopurinol, and within 2 hours, he experienced the same symptoms, requiring rehospitalization. He was diagnosed with suspected meningitis from an adverse drug reaction that we believe was due to allopurinol. It is important to remember, when all other causes are ruled out, that a patient's symptoms may be a drug-induced adverse effect. Drug-induced aseptic meningitis should be considered when patients with symptoms similar to those of infectious meningitis appear without infectious etiologies or cerebrospinal fluid pleocytosis, a suspected agent was recently started, and resolution of adverse effects occurs when the agent is withdrawn.
L E Greenberg; T Nguyen; S M Miller
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pharmacotherapy     Volume:  21     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-11-22     Completed Date:  2002-05-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1007-9     Citation Subset:  IM    
Department of Pharmacy Services, Ben Taub General Hospital, Houston, Texas 77030, USA.
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MeSH Terms
Allopurinol / adverse effects*,  therapeutic use
Diagnosis, Differential
Enzyme Inhibitors / adverse effects*,  therapeutic use
Kidney Calculi / drug therapy
Meningitis, Aseptic / chemically induced*,  diagnosis
Meningitis, Bacterial / diagnosis
Middle Aged
Xanthine Oxidase / antagonists & inhibitors
Reg. No./Substance:
0/Enzyme Inhibitors; 315-30-0/Allopurinol; EC Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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