Document Detail

Suspect novel adverse drug reactions to trimethoprim-sulphonamide combinations in horses: A case series.
MedLine Citation:
PMID:  21143643     Owner:  NLM     Status:  In-Data-Review    
Adverse drug reactions to trimethoprim-sulphonamide combinations are common in many species, manifesting as gastrointestinal tract disorders, dermatopathies and blood dyscrasias. In this case series, neurological abnormalities in 4 horses being treated with trimethoprim-sulphonamide combinations at normal dosages and in one foal that received an overdose are described. The horses developed hypermetric gait, agitation and erratic behaviour. All signs resolved once medication was withdrawn, and no horse had residual deficits. No other cause for observed neurological deficits could be determined. These clinical signs appear to represent a novel adverse drug reaction to some commonly used antimicrobial combinations.
A Stack; H C Schott Ii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Equine veterinary journal     Volume:  43     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  117-20     Citation Subset:  IM    
Copyright Information:
© 2010 EVJ Ltd.
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, USA.
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