Document Detail

Susceptibility to raf and raf/myc retroviruses is governed by different genetic loci.
MedLine Citation:
PMID:  2539530     Owner:  NLM     Status:  MEDLINE    
The susceptibility to tumors induced by raf and raf/myc retroviruses was investigated in BALB/c, C57BL/6, (BALB/c x C57BL/6)F1 and (BALB/c x C57BL/6) backcross mice. Newborn mice were susceptible to neoplasms generated by both viruses, but resistance to raf-induced leukemia developed rapidly in all mice as they matured. Older C57BL/6 mice were also resistant to raf/myc lymphomas, whereas BALB/c mice remained susceptible to the virus at all ages, indicating that different genes control susceptibility to raf and raf/myc tumors. From these data and the susceptibility of C x B recombinant inbred strains, it appears that very few genes (perhaps even a single gene) may govern susceptibility to raf/myc lymphomas and that resistance is the dominant trait.
S P Klinken; J W Hartley; T N Fredrickson; U R Rapp; H C Morse
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of virology     Volume:  63     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-05-18     Completed Date:  1989-05-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2411-4     Citation Subset:  IM    
Laboratory of Immunopathology, National Institutes of Health, Bethesda, Maryland 20892.
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MeSH Terms
Age Factors
Animals, Newborn / microbiology
Disease Susceptibility
Leukemia, Experimental / genetics*,  microbiology
Mice, Inbred Strains / genetics*
Oncogene Proteins, Viral / genetics*
Sarcoma Viruses, Murine / pathogenicity*
Grant Support
N01-A1-22673//PHS HHS
Reg. No./Substance:
0/Oncogene Proteins, Viral

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