| Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency. | |
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MedLine Citation:
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PMID: 20797909 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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It remains unclear why some individuals and not others are susceptible to non-tuberculous mycobacterial lung disease (NTMLD). To determine whether NTMLD is associated with defects or biases in Th1/Th2/Th17 immunity, blood leukocytes from NTM patients with nodular bronchiectasis, their adult offspring, and healthy population controls were stimulated with staphylococcal enterotoxin B (SEB), tuberculin and sensitin to measure cytokine production. In response to SEB, NTM patients exhibited higher frequencies of IFNγ-producing CD4(+) T cells than population controls (P<0.001). In supernatant, levels of IL-17 were lower in patients than adult offspring. Sensitin elicited higher IFNγ responses from patients than controls (P<0.05). Patients also produced more IL-10 in supernatant than controls after culture with tuberculin (P<0.01) or sensitin (P<0.05), but IL-10-producing CD4(+) T cells were undetectable. NTMLD is not associated with deficient IFNγ production, but may be associated with reduced Th17 immunity and/or a predisposition towards IL-10 production from non-CD4(+) T cells. |
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Authors:
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Andrew Lim; Caris Allison; Patricia Price; Grant Waterer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-24 |
Journal Detail:
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Title: Clinical immunology (Orlando, Fla.) Volume: 137 ISSN: 1521-7035 ISO Abbreviation: Clin. Immunol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 296-302 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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University of Western Australia, School of Pathology and Laboratory Medicine (Royal Perth Hospital campus), Level 2 Medical Research Foundation Building, Rear of 50 Murray Street, Perth, Western Australia, Australia, 6000. andrew.lim@uwa.edu.au |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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